Associated workgroup: The Liver-Brain Axis

Group members

Dr. Julica Inderhees, Christine Eichholz, Riccardo Costalunga

Research Interests

My group is interested in the liver-brain axis with special focus on ischemic stroke. Stroke is one of the leading causes of mortality and adult disability worldwide. Although there has been great progress in understanding the mechanisms following an ischemic event, treatment options are still limited. In the past, stroke research has focused mainly on intracerebral events following focal ischemia. Recently, the effect of acute ischemic stroke on other organs has received increasing attention and it is now widely accepted that stroke induces multiple alterations in the periphery. The liver is an important metabolic organ that plays a key regulatory role in glucose and energy homeostasis, lipid metabolism as well as detoxification and antioxidant systems. Our research interest is to investigate the connection between brain and liver under pathological conditions, focusing on changes in the liver metabolome and gene expression in animal or cell culture models. Our main expertise is in metabolomics and lipidomics approaches using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). 

https://www.cbbm.uni-luebeck.de/forschungszentrum/core-facilities/bioanalytic-core-facility 

Selected publications

Inderhees J, Schwaninger M (2024) Liver Metabolism in Ischemic Stroke. Neuroscience 550:62-8.

Rhein S, Inderhees J, Herrmann O, Othman A, Begemann K, Fleming T, Nawroth PP, Klika KD, Isa R, Konig IR, Royl G, Schwaninger M (2023) Glyoxal in hyperglycaemic ischemic stroke - a cohort study. Cardiovasc Diabetol 22:173.

Folberth J, Begemann K, Jöhren O, Schwaninger M, Othman A (2020) MS(2) and LC libraries for untargeted metabolomics: Enhancing method development and identification confidence. J Chromatogr B Analyt Technol Biomed Life Sci 1145:122105.