Publications

2017

Assmann JC, Müller K, Wenzel J, Walther T, Brands J, Thornton P, Allan SM, Schwaninger M. Isolation and Cultivation of Primary Brain Endothelial Cells from Adult Mice. Bio Protoc. 2017 May 20;7(10). pii: e2294. doi: 10.21769/BioProtoc.2294.

Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML. Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature. 2017 May 18;545(7654):305-310. doi: 10.1038/nature22075. Epub 2017 May 10.

Eskilsson A, Matsuwaki T, Shionoya K, Mirrasekhian E, Zajdel J, Schwaninger M, Engblom D, Blomqvist A. Immune-Induced Fever Is Dependent on Local But Not Generalized Prostaglandin E2 Synthesis in the Brain. J Neurosci. 2017 May 10;37(19):5035-5044. doi: 10.1523/JNEUROSCI.3846-16.2017. Epub 2017 Apr 24.

Müller K, Courtois G, Ursini MV, Schwaninger M. New insight into the pathogenesis of cerebral small-vessel diseases. Stroke. 2017. 48:00-00. doi: 10.1161/STROKEAHA.116.012888.

Mildner M, Müller-Fielitz H, Stölting I, Jöhren O, Steckelings M, Raasch W. Glucagon increase after chronic AT1 blockade is more likely related to an indirect leptin-dependent than to a pancreatic α-cell-dependent mechanism. Naunyn Schmiedebergs Arch Pharmacol. 2017 Jan 31. doi: 10.1007/s00210-017-1346-7. [Epub ahead of print] 

2016

Montes-Cobos E, Ring S, Fischer HJ, Heck J, Strauß J, Schwaninger M, Reichardt SD, Feldmann C, Lühder F, Reichardt HM. Targeted delivery of glucocorticoids to macrophages in amouse model of multiple sclerosis using inorganic-organic hybrid nanoparticles. J Control Release. 2017; 245: 157-169. doi: 10.1016/j.jconrel.2016.12.003.

Alecu I, Tedeschi A, Behler N, Wunderling K, Lamberz C, Lauterbach MA, Gaebler A, Ernst D, Van Veldhoven PP, Al-Amoudi A, Latz E, Othman A, Kuerschner L, Hornemann T, Bradke F, Thiele C, Penno A. Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction. J Lipid Res. 2016 Nov 23. doi: 10.1194/jlr.M068676. [Epub ahead of print]

Alecu I, Othman A, Penno A, Saied EM, Arenz C, von Eckardstein A, Hornemann T. Cytotoxic 1-Deoxysphingolipids Are Metabolized by a Cytochrome P450-Dependent Pathway. J Lipid Res. 2016 Nov 21. doi: 10.1194/jlr.M072421. [Epub ahead of print]

Koo PC, Marshall L. Neuroscience: A Sleep Rhythm with Multiple Facets. Curr Biol. 2016 Sep 12;26(17):R813-5. doi: 10.1016/j.cub.2016.07.027

Weigenand A, Mölle M, Werner F, Martinetz T, Marshall L. Timing matters: open-loop stimulation does not improve overnight consolidation of word pairs in humans. Eur J Neurosci. 2016 Sep;44(6):2357-68. doi: 10.1111/ejn.13334.

Schellenberger Costa M, Weigenand A, Ngo H-VV, Marshall L, Born J, Martinetz T, et al. A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation. PLoS Comput Biol 2016, 12(9): e1005022. doi:10.1371/journal.pcbi.1005022
Data and/or scripts are available on request.

Khan MA*, Schultz S*, Othman A, Fleming T, Lebrón-Galán R, Rades D, Clemente D, Nawroth PP, Schwaninger M. Hyperglycemia in stroke impairs polarization of monocytes/macrophages to a protective noninflammatory cell type. J Neurosci. 2016;36:9313-9325. *these authors contributed equally to this work

Ohnmacht J, Yang Y, Maurer GW, Barreiro-Iglesias A, Tsarouchas TM, Wehner D, Sieger D, Becker CG, Becker T. Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish. Development 2016 May 1, 143(9):1464-74. doi: 10.1242/dev.129155. 

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell 2016 May 5;165(4):882-95. doi: 10.1016/j.cell.2016.03.033. 

Muhammad S, Planz O, Schwaninger M. Increased Plasma Matrix Metalloproteinase-9 Levels Contribute to Intracerebral Hemorrhage during Thrombolysis after Concomitant Stroke and Influenza Infection. Cerebrovasc Dis Extra. 2016 Aug 25;6(2):50-59. [Epub ahead of print]

Zlomuzica A, Dere D, Binder S, De Souza Silva MA, Huston JP, Dere E. Neuronal histamine and cognitive symptoms in Alzheimer's disease. Neuropharmacology, 2016 Jul;106:135-45. doi: 10.1016/j.neuropharm.2015.05.007

Hirose M, Schilf P, Lange F, Mayer J, Reichart G, Maity P, Jöhren O, Schwaninger M, Scharffetter-Kochanek K, Sina C, Sadik CD, Köhling R, Miroux B, Ibrahim SM. Uncoupling protein 2 protects mice from aging. Mitochondrion 2016 Jun 27;30:42-50. doi: 10.1016/j.mito.2016.06.004. [Epub ahead of print] 

Wenzel J, Schwaninger M. The blood–brain barrier and its regulation by NF-κB. e-Neuroforum 2016, 7: 23. doi:10.1007/s13295-016-0022-6

Steiner R, Mostafa E, Othman A, Arenz C, Maccarone AT, Poad BL, Blanksby SJ, von Eckardstein A, Hornemann T. Elucidating the chemical structure of native 1-deoxysphingosine. J Lipid Res. 2016 May 10. pii: jlr.M067033. [Epub ahead of print].

Körbelin J, Dogbevia G, Michelfelder S, Ridder DA, Hunger A, Wenzel J, Seismann H, Lampe M, Bannacj J, Pasparakis M, Kleinschmidt JA, Schwaninger M, Trepel M. A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases. EMBO Molecular Medicine 2016 Apr 22, doi: 10.15252/emmm.201506078 [Epub ahead of print].

Mustafa S, Martin HL, Burkly L, Costa A, Martins ML, Schwaninger M, Teismann P. The role of TWEAK/Fn14 signaling in the MPTP-model of Parkinson's disease. Neuroscience 2016 Apr 5, 319:116-22. doi: 10.1016/j.neuroscience.2016.01.034

Blank T, Detje CN, Spieß A, Hagemeyer N, Brendecke SM, Wolfart J, Staszewski O, Zöller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel ULM, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Müller M, Goelz SE, Baker DP, Schwaninger M, Kann O, Heikenwalder M, Kalinke U, Prinz M. Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment. Immunity 2016, 44(4):901-912. doi:10.1016/j.immuni.2016.04.005.

Dogbevia GK, Roßmanith M, Sprengel R, Hasan MT. Flexible, AAV-equipped Genetic Modules for Inducible Control of Gene Expression in Mammalian Brain. Mol Ther Nucleic Acids 2016, Apr 12;5:e309. doi: 10.1038/mtna.2016.23.

Güntert T, Hänggi P, Othman A, Suriyanarayanan S, Sonda S, Zuellig R.A, Hornemann T, Ogunsholaa OO. 1-Deoxysphingolipid-induced neurotoxicity involves N-methyl-D-aspartate receptor signaling. Neuropharmacology 2016, 23 March 2016. doi:10.1016/j.neuropharm.2016.03.033

Ziv C, Malitsky S, Othman A, Ben-Dor S, Wei Y,  Zheng S, Aharoni A, Hornemann H, Vardi A. Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga. PNAS 2016; published ahead of print March 16, 2016, doi:10.1073/pnas.1523168113.

Lopes Pinheiro MA, Kooij G, Mizee MR, Kamermans A, Enzmann G, Lyck R, Schwaninger M, Engelhardt B, de Vries HE. Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke. Biochim Biophys Acta, 2016 Mar;1862(3):461-71. doi: 10.1016/j.bbadis.2015.

Vries HE, Schwaninger M. Neuroinflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease. Biochim Biophys Acta, 2016 Mar;1862(3):297-8. doi: 10.1016/j.bbadis.2015.12.024 .

Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Björk Wilhelms D, Lazarus M, Löfberg A, Jaarola M, Örtegren Kugelberg U, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Rodriguez Parkitna J, Saper CB, Blomqvist A, Engblom D. Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice. J Clin Invest, 2016 Feb;126(2):695-705. doi: 10.1172/JCI83844.

Bode H, Bourquin F, Suriyanarayanan S, Wei Y, Alecu I, Othman A, von Eckardstein A, Hornemann T. HSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship. Hum Mol Genet, 2016, 25 (5): 853-865. doi:10.1093/hmg/ddv611.

Worzfeld T, Schwaninger M. Apicobasal polarity of brain endothelial cells. J Cereb Blood Flow Metab, 2016 Feb;36(2):340-62. doi: 10.1177/0271678X15608644.

Maysami S, Wong R, Pradillo JM, Denes A, Dhungana H, Malm T, Koistinaho J, Orset C, Rahman M, Rubio M, Schwaninger M, Vivien D, Bath PM, Rothwell NJ, Allan SM.  A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke. J Cereb Blood Flow Metab, 2016 Mar;36(3):596-605. doi: 10.1177/0271678X15606714.

Gliem M, Schwaninger M, Jander S. Protective features of peripheral monocytes/macrophages in stroke. Biochim Biophys Acta, 2016 Mar;36(3):596-605. doi: 10.1177/0271678X15606714.

Assmann JC, Körbelin J, Schwaninger M. Genetic manipulation of brain endothelial cells in vivo. Biochim Biophys Acta, 2016 Mar;1862(3):381-94. doi: 10.1016/j.bbadis.2015.10.006.

Qadri F, Rimmele F, Mallis L, Häuser W, Dendorfer A, Jöhren O, Dominiak P, Leeb-Lundberg LM, Bader M. Acute hypothalamo-pituitary-adrenal axis response to LPS-induced endotoxemia: expression pattern of kinin type B1 and B2 receptors. Biol Chem, 2016 Jan 1;397(2):97-109. doi: 10.1515/hsz-2015-0206.

Winkler M, Schuchard J, Stölting I, Vogt FM, Barkhausen J, Thorns C, Bader M, Raasch W. The brain renin-angiotensin system plays a crucial role in regulating body weight in diet-induced rat obesity. Br J Pharmacol, 2016, Feb 19. doi: 10.1111/bph.13461. [Epub ahead of print].

Storck SE, Meister S, Nahrath J, Meißner JN, Schubert N, Di Spiezio A, Baches S, Vandenbroucke RE, Bouter Y, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer TA, Pietrzik CU. 1. Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier. J Clin Invest, 2016 Jan;126(1):123-36. doi: 10.1172/JCI81108.

Sutter I, Klingenberg R, Othman A, Rohrer L, Landmesser U, Hege D, Rodondi N, Mach F, Windecker S, Matter C.M, Lüscher TF, von Eckardstein A, Hornemann T. Decreased phosphatidylcholine plasmalogens – A putative novel lipid signature in patients with stable coronary artery disease and acute myocardial infarction. Atherosclerosis 2016, doi:10.1016/j.atherosclerosis.2016.01.003.

Nach oben

2015

Blanke K, Schlegel F, Dhein S, Raasch W, Bader M, Dähnert I, Salameh A. Effect of angiotensin(1-7) on heart function in an experimental rat model of obesity. Front Physiol, 2015, 6:392, doi: 10.3389/fphys.2015.00392.

Corbin JC , Othman A, Allan JD, Worsnop DR, Haskins JD, Sierau B, Lohmann U, Mensah AA. Peak-fitting and integration imprecision in the Aerodyne aerosol mass spectrometer: effects of mass accuracy on location-constrained fits. Atmos Meas Tech, 2015, 8:4615-4636, doi:10.5194/amt-8-4615-2015.

Mueller DM, Allenspach M, Othman A, Saely CH, Muendlein A, Vonbank A, Drexel H, von Eckardstein A. Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control. Atherosclerosis, 2015, doi:10.1016/j.atherosclerosis.2015.10.091

Wilde C, Bruder R, Binder S, Marshall L, Schweikard A. Closed-loop transcranial alternating current stimulation of slow oscillations. CDBME, 2015; 1:85-88. doi:10.1515/cdbme-2015-0022.

Ridder DA*, Wenzel J*, Müller K, Töllner K, Tong X-K, Assmann JC, Stroobants S, Weber T, Niturad C, Fischer L, Lembrich B, Wolburg H, Grand’Maison M, Papadopoulos P, Korpos E, Truchetet F, Rades D, Sorokin LM, Schmidt-Supprian M, Bedell BJ, Pasparakis M, Balschun D, D’Hooge R, Löscher W, Hamel E, Schwaninger M. Brain endothelial TAK1 and NEMO safeguard the neurovascular unit. J Exp Med, 2015 Sep 7. jem20150165 doi:101084 [Epub ahead of print](*these authors contributed equally to this work)

Schultz S, Khan M, Schwaninger M. The decrease of M-CSF expression in the brain endothelium by acute hyperglycemia leads to a reduction in tissue protective M2 macrophages after ischemic stroke. Am J Hematol, 2015, 90(8), E167-E167.  

Westerberg CE, Florczak SM, Weintraub S, Mesulam MM, Marshall L, Zee PC, Paller KA. Memory improvement via slow-oscillatory stimulation during sleep in older adults. Neurobiol Aging, 2015, 36:2577-86.

Kramer R, Bielawski J, Kistner-Griffin E, Othman A, Alecu I, Ernst D, Kornhauser D, Hornemann T, Spassieva S: Neurotoxic 1-deoxysphingolipids and paclitaxel-induced peripheral neuropathy. FASEBJ, 2015 Jul 21. pii: fj.15-272567. [Epub ahead of print]

Othman A, Benghozi R,  Alecu A,  Wei Y, Niesor E, von Eckardstein A,  Hornemann T. Fenofibrate Lowers Atypical Sphingolipids in Plasma of Dyslipidemic Patients – a Novel Approach for Treating Diabetic Neuropathy? J Clin Lipidol, 2015; 9:568-575.

Binder S, Dere E, Zlomuzica A.  A critical appraisal of the what-where-when episodic-like memory test in rodents: Achievements, caveats and future directions. Prog Neurobiol, 2015 Jul; 130:71-85. doi: 10.1016/j.pneurobio.2015.04.002.

Schwaninger M. Fumarsäure oder Dimethylfumarat? Der Nervenarzt, 2015 Jun;86(6):756-757. doi:10.1007/s00115-014-4203-07.

Schade D, Kotthaus J, Riebling L, Kotthaus J, Müller-Fielitz H, Raasch W, Hoffmann A, Schmidtke M, Clement B. Zanamivir Amidoxime- and N Hydroxyguanidine-Based Prodrug Approaches to Tackle Poor Oral Bioavailability. J Pharm Sci, 2015 Sep;104(9):3208-19. doi: 10.1002/jps.24508.

Dohrn MF, Othman A, Hirshman SK, Bode H, Alecu I, Fahndrich E, Karges W, Weis J, Schulz JB, Hornemann T, Claeys KG. Elevation of plasma 1-deoxy-sphingolipids in type 2 diabetes mellitus: a susceptibility to neuropathy? Eur J Neurol, 2015;May, 22(5):806-814, e855. doi: 10.1111/ene.12663.

Othman A, Saely CH, Muendlein A, Vonbank A, Drexel H, von Eckardstein A, Hornemann T. Plasma C20-Sphingolipids predict cardiovascular events independently from conventional cardiovascular risk factors in patients undergoing coronary angiography. Atherosclerosis 2015 May;240(1):216-221.doi: 10.1016/j.atherosclerosis.2015.03.011.

Schuchard J, Winkler M, Stoelting I, Schuster F, Vogt F, Barkhausen J, Thorns C, Santos RA, Bader M, Raasch W. Lack of weight gain after angiotensin AT(1) receptor blockade in diet-induced obesity is partly mediated by an angiotensin-(1-7)/Mas-dependent pathway. Br J Pharmacol, 2015 Aug;172(15):3764-78. doi: 10.1111/bph.13172.

Dogbevia GK, Marticorena-Alvarez R, Bausen M, Sprengel R, Hasan MT. Inducible and combinatorial gene manipulation in mouse brain. Front Cell Neurosci, 2015, Apr 21, doi: 10.3389/fncel.2015.00142.

Offermanns S, Schwaninger M. Nutritional or pharmacological activation of HCA2 ameliorates neuroinflammation. Trends Mol Med, 2015 Apr;21(4):245-255. doi: 10.1016/j.molmed.2015.02.002.

Ernst D, Murphy SM, Sathiyanadan K, Wei Y, Othman A, Laura M, Liu YT, Penno A, Blake J, Donaghy M, Houlden H, Reilly MM, Hornemann T. Novel HSAN1 Mutation in Serine Palmitoyltransferase Resides at a Putative Phosphorylation Site That Is Involved in Regulating Substrate Specificity. Neuromolecular Med, 2015, March,17(1):47-57.  doi: 10.1007/s12017-014-8339-1.

Othman A, Saely CH, Muendlein A, Vonbank A, Drexel H, von Eckardstein A, Hornemann T. Plasma 1-deoxysphingolipids are predictive biomarkers for type 2 diabetes mellitus. BMJ Open Diabetes Res Care, 2015 Mar;3(1):e000073. doi: 10.1136/bmjdrc-2014-000073.

Othman A, Bianchi R, Alecu I, Wei Y, Porretta-Serapiglia C, Lombardi R, Chiorazzi A, Meregalli C, Oggioni N, Cavaletti G, Lauria G, von Eckardstein A, Hornemann T. Lowering plasma 1-deoxysphingolipids improves neuropathy in diabetic rats. Diabetes, 2015 Mar;64(3):1035-1045. doi: 10.2337/db14-1325.

Müller-Fielitz H, Lau M, Geißler C, Werner L, Winkler M, Raasch W. Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats. Br J Pharmacol, 2015 Feb; 172(3):857-68. doi: 10.1111/bph.12949. Epub 2014 Nov 24.

Assmann JC, Chen H, Okun JG, Wettschureck N, Schwaninger M. The role of the hydroxycarboxylic acid receptor 2 in mice on a ketogenic diet in experimental autoimmune encephalomyelitis. Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, 388(1) Supplement, S49-S49.

Mueller K, Ridder DA, Wenzel J, van Loo G, Schwaninger M. TAK1-IKK-NF kappa B-signaling contributes to blood-brain barrier integrity. Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, 388(1) Supplement, S30-S30.

Mueller-Fielitz H, Stahr M, Bernau M, Schwaninger M. beta-Tanycytes in the regulation of the hypothalamus-pituitary-thyroid-axis. Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, 388(1) Supplement, S25-S25.

Ohnmacht J, Schwaninger M. Analysis of circadian regulation of gene expression in CNS microvascular endothelial cells. Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, 388(1) Supplement, S30-S30.

Schultz S, Khan, MA, Schwaninger M. Acute hyperglycemia is an important modulator of the inflammatory response after ischemic stroke. Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, 388(1) Supplement, S31-S31.

Nach oben

2014

Eskilsson A, Mirrasekhian E, Dufour S, Schwaninger M, Engblom D, Blomqvist A. Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent induction of brain endothelial prostaglandin synthesis. J Neurosci. 2014 Nov 26;34(48):15957-61.

Purrucker JC, Herrmann O, Lutsch JK, Zorn M, Schwaninger M, Bruckner T, Auffarth GU, Veltkamp R. Serum Protein S100β is a Diagnostic Biomarker for Distinguishing Posterior Circulation Stroke from Vertigo of Nonvascular Causes. Eur Neurol. 2014 Oct 16;72(5-6):278-284.

Wilhelms DB, Kirilov M, Mirrasekhian E, Eskilsson A, Kugelberg UÖ, Klar C, Ridder DA, Herschman HR, Schwaninger M, Blomqvist A, Engblom D. Deletion of prostaglandin e2 synthesizing enzymes in brain endothelial cells attenuates inflammatory Fever. J Neurosci. 2014 Aug 27;34(35):11684-90.

Rahman M, Muhammad S, Khan MA, Chen H, Ridder DA, Müller-Fielitz H, Pokorna B, Vollbrandt T, Stölting I, Nadrowitz R, Okun JG, Offermanns S, Schwaninger M. The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages. Nat Commun. 2014 May;5:3944.

Chen H, Assmann JC, Krenz A, Rahman M, Grimm M, Karsten CM, Köhl J, Offermanns S, Wettschureck N, Schwaninger M. Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE. J Clin Invest. 2014 May;124(5):2188-92.

Wernecke K, Lamprecht I, Jöhren O, Lehnert H, Schulz C. Nesfatin-1 increases energy expenditure and reduces food intake in rats. Obesity (Silver Spring). 2014 Jul;22(7):1662-8

Binder S, Berg K, Gasca F, Lafon B, Parra LC, Born J, Marshall L. Transcranial Slow Oscillation Stimulation During Sleep Enhances Memory Consolidation in Rats. Brain Stimul. 2014 Jul-Aug;7(4):508-15
Data and/or scripts are available here.

Heinonen AM, Rahman M, Dogbevia G, Jakobi H, Wölfl S, Sprengel R, Schwaninger M. Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7. BMC Neurosci. 2014 Mar;15(1):38.

Müller-Fielitz H, Hübel N, Mildner M, Vogt FM, Barkhausen J, Raasch W. Chronic blockade of angiotensin AT1 receptors improves cardinal symptoms of metabolic syndrome in diet-induced obesity in rats. Br J Pharmacol. 2014 Feb;171(3):746-60.

Schade D, Kotthaus J, Riebling L, Kotthaus J, Müller-Fielitz H, Raasch W, Koch O, Seidel N, Schmidtke M, Clement B. Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A. J Med Chem. 2014 Feb;57(3):759-69.

Binder S, Rawohl J, Born J, Marshall L. Transcranial slow oscillation stimulation during NREM sleep enhances acquisition of the radial maze task and modulates cortical network activity in rats. Front Behav Neurosci. 2014 Jan;7:220.
Data and/or scripts are available on request.

Nach oben

2013

Wenzel J, Assmann JC, Schwaninger M. Thrombomodulin - a New Target for Treating Stroke at the Crossroad of Coagulation and Inflammation. Curr Med Chem. 2014;21(18):2025-34.

Hasan MT, Hernández-González S, Dogbevia G, Treviño M, Bertocchi I, Gruart A, Delgado-García JM. Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice. Nat Commun. 2013 Aug 27;4:2258.

Ramanjaneya M, Karteris E, Chen J, Rucinski M, Ziolkowska A, Ahmed N, Kagerer S, Jöhren O, Lehnert H, Malendowicz LK, Randeva HS. QRFP induces aldosterone production via PKC and T-type calcium channel mediated pathways in human adrenocortical cells: evidence for a novel role of GPR103. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):1049-58 

Murphy SR, Chang CC, Dogbevia G, Bryleva EY, Bowen Z, Hasan MT, Chang TY. Acat1 Knockdown Gene Therapy Decreases Amyloid-β in a Mouse Model of Alzheimer's Disease. Mol Ther. 2013 Aug;21(8):1497-506. 

Rosell A, Agin V, Rahman M, Morancho A, Ali C, Koistinaho J, Wang X, Vivien D, Schwaninger M, Montaner J. Distal Occlusion of the Middle Cerebral Artery in Mice: Are We Ready to Assess Long-Term Functional Outcome? Transl Stroke Res. 2013 Jun;4(3):297-307.

Barclay JL, Shostak A, Leliavski A, Tsang AH, Jöhren O, Müller-Fielitz H, Landgraf D, Naujokat N, van der Horst GT, Oster H. High fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry deficient mice. Am J Physiol Endocrinol Metab. 2013 May;304(10):1053-63.

Mc Guire C, Rahman M, Schwaninger M, Beyaert R, van Loo G. The ubiquitin editing enzyme A20 (TNFAIP3) is upregulated during permanent middle cerebral artery occlusion but does not influence disease outcome. Cell Death Dis. 2013 Mar;4:531. 

Ruud J, Wilhelms DB, Nilsson A, Eskilsson A, Tang YJ, Ströhle P, Caesar R, Schwaninger M, Wunderlich T, Bäckhed F, Engblom D, Blomqvist A. Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells. FASEB J. 2013 May;27(5):1973-80.

Müller-Fielitz H, Raasch W. Angiotensin II Impairs Glucose Utilization in Obese Zucker Rats by Increasing HPA Activity via an Adrenal-dependent Mechanism. Horm Metab Res. 2013 Feb;45(2):173-80.

Nach oben

2012

Djuric Z, Muhammed K, Fleming T, Murikinati S, Piel D, Von Bauer R, Bea F, Herzig S, Zeier M, Liou HC, Pizzi M, Isermann B, Hecker M, Schwaninger M, Bierhaus A, Nawroth PP. Targeting NFKB subunit-specific activation prevents stress-dependent atherothrombotic gene expression. Mol Med. 2012 Dec;18:1375-86.

Bargiotas P, Krenz A, Monyer H, Schwaninger M. Functional outcome of pannexin-deficient mice after cerebral ischemia. Channels (Austin). 2012 Nov;6(6):453-6.

Ridder DA, Schwaninger M. In search of the neuroprotective mechanism of thiazolidinediones in Parkinson's disease. Exp Neurol. 2012 Dec;238(2):133-7.

Ridder DA, Schwaninger M. TAK1 inhibition for treatment of cerebral ischemia. Exp Neurol. Exp Neurol. 2013 Jan;239:68-72.

Hertel S, Schwaninger M, Helmchen C. Combined toxicity of penicillin and aspirin therapy may elicit bilateral vestibulopathy. Clin Neurol Neurosurg. 2013 Jul;115(7):1114-6.

Bargiotas P, Muhammad S, Rahman M, Jakob N, Trabold R, Fuchs E, Schilling L, Plesnila N, Monyer H, Schwaninger M. Connexin 36 promotes cortical spreading depolarization and ischemic brain damage. Brain Res. 2012 Oct;1479:80-5. Direct Link#

Pientka FK, Hu J, Schindler SG, Brix B, Thiel A, Jöhren O, Fandrey J, Berchner-Pfannschmidt U, Depping R. Oxygen sensing by Prolyl-4-Hydroxylase PHD2 within the nuclear compartment and the influence of compartimentalisation on HIF-1 signalling. J Cell Sci. 2012 Nov;125(Pt 21):5168-76.

Brix B, Mesters JR, Pellerin L, Jöhren O. Endothelial Cell-Derived Nitric Oxide Enhances Aerobic Glycolysis in Astrocytes via HIF-1alpha-Mediated Target Gene Activation. J Neurosci. 2012 Jul;32(28):9727-35.

Bieganska K, Sokolowska P, Jöhren O, Zawilska JB. Orexin A Suppresses the Growth of Rat C6 Glioma Cells via a Caspase-Dependent Mechanism. J Mol Neurosci. 2012 Nov;48(3):706-12.

A. Bierhaus, T. Fleming, S. Stoyanov, A. Leffler, A. Babes, C. Neacsu, S. K. Sauer, M. Eberhardt, M. Schnölzer, F. Lasischka, W. L. Neuhuber, T. I. Kichko, I. Konrade, R. Elvert, W. Mier, V. Pirags, I. K. Lukic, M. Morcos, T. Dehmer, N. Rabbani, P. J. Thornalley, D.e Edelstein, C. Nau, J. Forbes, P. M. Humpert, M. Schwaninger, D. Ziegler, D. M. Stern, M. E. Cooper, U. Haberkorn, M. Brownlee, P. W. Reeh, P. P. Nawroth. Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nat Med. 2012 Jun;18(6):926-33. 

Werner L, Müller-Fielitz H, Ritzal M, Werner T, Rossner M, Schwaninger M. Involvement of Doublecortin-Expressing Cells in the Arcuate Nucleus in Body Weight Regulation. Endocrinology. 2012 Jun;153(6):2655-64.

Finol-Urdaneta RK, Remedi MS, Raasch W, Becker S, Clark RB, Strüver N, Pavlov E, Nichols CG, French RJ, Terlau H. Block of K(v) 1.7 potassium currents increases glucose-stimulated insulin secretion. EMBO Mol Med. 2012 May;4(5):424-34. 

Ashoff A, Qadri F, Eggers R, Jöhren O, Raasch W, Dendorfer A. Pioglitazone Prevents Capillary Rarefaction in Streptozotocin-Diabetic Rats Independently of Glucose Control and Vascular Endothelial Growth Factor Expression. J Vasc Res. 2012 Mar;49(3):260-266.

Müller-Fielitz H, Lau M, Jöhren O, Stellmacher F, Schwaninger M, Raasch W. Blood Pressure Response to Angiotensin II is Enhanced in Obese Zucker Rats and is Attributed to an Aldosterone-Dependent Mechanism. Br J Pharmacol. 2012 Aug;166(8):2417-29

Miesel A, Müller Fielitz H, Jöhren O, Vogt FM, Raasch W: Double blockade of angiotensin II (AT(1) )-receptors and ACE does not improve weight gain and glucose homeostasis better than single-drug treatments in obese rats. Br J Pharmacol. 2012 Apr; 165(8):2721-35.

Müller-Fielitz H, Landolt J, Heidbreder M, Werth S, Vogt FM, Jöhren O, Raasch W. Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPAR? target gene regulation.  Endocrinology. 2012 Mar;153(3):1103-15.

Lohmann K, Uflacker N, Erogullari A, Lohnau T, Winkler S, Dendorfer A, Schneider SA, Osmanovic A, Svetel M, Ferbert A, Zittel S, Kühn AA, Schmidt A, Altenmüller E, Münchau A, Kamm C, Wittstock M, Kupsch A, Moro E, Volkmann J, Kostic V, Kaiser FJ, Klein C, Brüggemann N. Identification and functional analysis of novel THAP1 mutations. Eur J Hum GenetEur J Hum Genet. 2012 Feb;20(2):171-5.

Schulz C, Paulus K, Jöhren O, Lehnert H. Intranasal leptin reduces appetite and induces weight loss in rats with diet-induced obesity (DIO). Endocrinology. 2012 Jan;153(1):143-53

Hakim SG, Benedek GA, Su YX, Jacobsen HC, Klinger M, Dendorfer A, Hemmelmann C, Meller B, Nadrowitz R, Rades D, Sieg P. Radioprotective Effect of Lidocaine on Function and Ultrastructure of Salivary Glands Receiving Fractionated Radiation. Int J Radiat Oncol Biol Phys. 2012 Mar 15;82(4):e623-30.

Urbanska A, Sokorowska P, Woldan-Tambor A, Bieganska K, Brix B, Jöhren O, Namiecinska M, Zawilska JB. Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures. J Mol Neurosci. 2012 Jan;46(1):10-7

Brandenburger M*, Wenzel J*, Bogdan R, Richardt D, Nguemo F, Reppel M, Hescheler J, Terlau H, Dendorfer A. Organotypic slice culture from human adult ventricular myocardium. Cardiovasc Res. 2012 Jan;93(1):50-9. (*contributed equally to this work)

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2011

Schwaninger M (2011) Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universität zu Lübeck. In: Geschichte und Wirken der pharmakologischen, klinisch-pharmakologischen und toxikologischen Institute im deutschsprachigen Raum. Hrsg.: A. Philippu. Berenkamp.

Bargiotas P, Krenz A, Hormuzdi SG, Ridder DA, Herb A, Barakat W, Penuela S, von Engelhardt J, Monyer H, Schwaninger M. Pannexins in ischemia-induced neurodegeneration. Proc Natl Acad Sci U S A. 2011 Dec;108(51):20772-7.

Ridder DA, Lang MF, Salinin S, Röderer JP, Struss M, Maser-Gluth C, Schwaninger M. TAK1 in brain endothelial cells mediates fever and lethargy. J Exp Med. 2011 Dec;208(13):2615-23.

Kotthaus J, Kotthaus J, Schade D, Schwering U, Hungeling H, Müller-Fielitz H, Raasch W, Clement B. New prodrugs of the antiprotozoal drug pentamidine.
ChemMedChem. 2011 Dec ;6:2233-42

Lang MF, Salinin S, Ridder DA, Kleesiek J, Hroudova J, Berger S, Schütz G, Schwaninger M. A transgenic approach to identify thyroxine transporter-expressing structures in brain development. J Neuroendocrinol. 2011 Dec;23(12):1194-203

Marcillac F, Brix B, Repond C, Jöhren O, Pellerin L. Nitric oxide induces the expression of the monocarboxylate transporter MCT4 in cultured astrocytes by a cGMP-independent transcriptional activation. Glia. 2011 Dec;59(12):1987-95.


Neubert M*, Ridder DA*, Bargiotas P, Akira S, Schwaninger M. Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia. Cell Death Differ. 2011 Sep;18(9):1521-30 (*These authors contributed equally to this work.)


Belge G, Radtke A, Meyer A, Stegen I, Richardt D, Nimzyk R, Nigam V, Dendorfer A, Sievers HH, Tiemann M, Buchwalow I, Bullerdiek J, Mohamed SA. Upregulation of the high mobility group AT-hook 2 gene in acute aortic dissection is potentially associated with endothelial-mesenchymal transition. Histol Histopathol. 2011 Aug;26(8):1029-37.

Osmanovic A, Dendorfer A, Erogullari A, Uflacker N, Braunholz D, Rakovic A, Vierke G, Gil-Rodríguez C, Münchau A, Albrecht M, Brüggemann N, Gillessen-Kaesbach G, Klein C, Lohmann K, Kaiser FJ. Truncating mutations in THAP1 define the nuclear localization signal. Mov Disord. 2011 Jul;26(8):1565-7

Müller-Fielitz H, Markert A, Wittmershaus C, Pahlke F, Jöhren O, Raasch W.
Weight loss and hypophagia after high-dose AT1-blockade is only observed after high dosing and depends on regular leptin signalling but not blood pressure. Naunyn Schmiedebergs Arch Pharmacol. 2011 Apr;383(4):373-84.

Kagerer SM, Eichholz C, Jöhren O. Orexins/hypocretins increase the promoter activity of selective steroidogenic enzymes. Peptides. 2011 Apr;32(4):839-43.

Zhang SJ, Buchthal B, Lau D, Hayer S, Dick O, Schwaninger M, Veltkamp R, Zou M, Weiss U, Bading H. A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage. J Neurosci. 2011 Mar;31(13):4978-90.

Muhammad S, Haasbach E, Kotchourko M, Strigli A, Krenz A, Ridder DA, Vogel AB, Marti HH, Al-Abed Y, Planz O, Schwaninger M. Influenza virus infection aggravates stroke outcome. Stroke. 2011 Mar;42(3):783-91.

Schindowski K, von Bohlen und Halbach O, Strelau J, Ridder DA, Herrmann O, Schober A, Schwaninger M, Unsicker K. Regulation of GDF-15, a distant TGF-β superfamily member, in a mouse model of cerebral ischemia. Cell Tissue Res. 2011 Feb;343(2):399-409.

Grunow B, Wenzel J, Terlau H, Langner S, Gebert M, Kruse C. In vitro developed spontaneously contracting cardiomyocytes from rainbow trout as a model system for human heart research. Cell Physiol Biochem. 2011;27(1):1-12.

Schölzke MN, Röttinger A, Murikinati S, Gehrig N, Leib C, Schwaninger M. TWEAK regulates proliferation and differentiation of adult neural progenitor cells. Mol Cell Neurosci. 2011 Jan;46(1):325-32.

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2010

Leiblein J, Dominiak P.
Das Herz-Kreislauf-Telefon der Deutschen Hochdruckliga e.V. DHL® in der Beurteilung der Anrufer: Ergebnisse einer Rückfrageaktion.
Dtsch Med Wochenschr. 2010 Dec;135(48):2426-7.
Abstract

Kreuzberg M, Kanov E, Timofeev O, Schwaninger M, Monyer H, Khodosevich K.
Increased subventricular zone-derived cortical neurogenesis after ischemic lesion.
Exp Neurol. 2010 Nov;226(1):90-9.
Abstract


Frauenknecht K, Bargiotas P, Bauer H, von Landenberg P, Schwaninger M, Sommer C.
Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody.
J Neuroimmunol. 2010 Oct 8;227(1-2):1-9.
Abstract

Leiblein J, Dominiak P.
Blutdruckselbstmessung: Zwei telefonische Befragungen am Herz-Kreislauf-Telefon.
Dtsch Med Wochenschr. 2010 Aug;135(31-32):1559-60.
Abstract


Muhammad S, Aller MI, Maser-Gluth C, Schwaninger M, Wisden W.
Expression of the kcnk3 potassium channel gene lessens the injury from cerebral ischemia, most likely by a general influence on blood pressure.
Neuroscience. 2010 May 19;167(3):758-64.
Abstract

Chen P, Dendorfer A, Finol-Urdaneta RK, Terlau H, Olivera BM.
Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins.
J Biol Chem. 2010 May 14;285(20):14882-9.
Abstract

Elzer JG, Muhammad S, Wintermantel TM, Regnier-Vigouroux A, Ludwig J, Schütz G, Schwaninger M.
Neuronal estrogen receptor-alpha mediates neuroprotection by 17beta-estradiol.
J Cereb Blood Flow Metab. 2010 May;30(5):935-42.
Abstract

Rompe F, Artuc M, Hallberg A, Alterman M, Ströder K, Thöne-Reineke C, Reichenbach A, Schacherl J, Dahlöf B, Bader M, Alenina N, Schwaninger M, Zuberbier T, Funke-Kaiser H, Schmidt C, Schunck WH, Unger T, Steckelings UM.
Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB.
Hypertension. 2010 Apr;55(4):924-31.
Abstract

Kagerer SM, Jöhren O.
Interactions of orexins/hypocretins with adrenocortical functions.
Acta Physiol (Oxf). 2010 Mar;198(3):361-71.
Abstract

Murikinati S, Jüttler E, Keinert T, Ridder DA, Muhammad S, Waibler Z, Ledent C, Zimmer A, Kalinke U, Schwaninger M.
Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment.
FASEB J. 2010 Mar;24(3):788-98.
Abstract

Chaitanya GV, Schwaninger M, Alexander JS, Babu PP.
Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemia in rat model.
Neuroscience. 2010 Feb 17;165(4):1203-16.
Abstract

Perwitz N, Wenzel J, Wagner I, Büning J, Drenckhan M, Zarse K, Ristow M, Lilienthal W, Lehnert H, Klein J.
Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes.
Diabetes Obes Metab. 2010 Feb;12(2):158-66.

Overfeeding-induced obesity in spontaneously hypertensive rats: an animal model of the human metabolic syndrome.
Miesel A, Müller H, Thermann M, Heidbreder M, Dominiak P, Raasch W.
Ann Nutr Metab. 2010;56(2):127-42.
Abstract


Müller H, Kröger J, Jöhren O, Szymczak S, Bader M, Dominiak P, Raasch W.
Stress sensitivity is increased in transgenic rats with low brain angiotensinogen.
J Endocrinol. 2010 Jan;204(1):85-92.
Abstract

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2009

Burgdorf C, Hänsel L, Heidbreder M, Jöhren O, Schütte F, Schunkert H, Kurz T.
Suppression of cardiac phosphatidate phosphohydrolase 1 activity and lipin mRNA expression in Zucker diabetic fatty rats and humans with type 2 diabetes mellitus.
Biochem Biophys Res Commun. 2009 Dec 4;390(1):165-70.
Abstract

Wenzel J, Grabinski N, Knopp CA, Dendorfer A, Ramanjaneya M, Randeva HS, Ehrhart-Bornstein M, Dominiak P, Jöhren O.
Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells.
Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1601-9.
Abstract

Leiblein J, Dominiak P.
Analyse von 20000 Anrufen bei der Telefon-Hotline der Deutschen Hochdruckliga e.V. DHL®.
Dtsch Med Wochenschr. 2009 Nov;134(45):2270-3.
Abstract


Lubjuhn J, Gastens A, von Wilpert G, Bargiotas P, Herrmann O, Murikinati S, Rabie T, Marti HH, Amende I, Hampton TG, Schwaninger M.
Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery.
J Neurosci Methods. 2009 Oct 30;184(1):95-103. Erratum in: J Neurosci Methods. 2010 Jan 30;186(1):140. Marti, Hugo [corrected to Marti, Hugo H].
Abstract

Ramot Y, Gáspár E, Dendorfer A, Langbein L, Paus R.
The 'melanocyte-keratin' mystery revisited: neither normal human epidermal nor hair follicle melanocytes express keratin 16 or keratin 6 in situ.
Br J Dermatol. 2009 Oct;161(4):933-8.
Abstract

Humpert PM, Lukic IK, Thorpe SR, Hofer S, Awad EM, Andrassy M, Deemer EK, Kasper M, Schleicher E, Schwaninger M, Weigand MA, Nawroth PP, Bierhaus A.
AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis.
J Leukoc Biol. 2009 Sep;86(3):589-97.
Abstract

Ramanjaneya M, Conner AC, Chen J, Kumar P, Brown JE, Jöhren O, Lehnert H, Stanfield PR, Randeva HS.
Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B.
J Endocrinol. 2009 Aug;202(2):249-61.
Abstract

Barakat W, Herrmann O, Baumann B, Schwaninger M.
NF-kappaB induces PGE2-synthesizing enzymes in neurons.
Naunyn Schmiedebergs Arch Pharmacol. 2009 Aug;380(2):153-60.
Abstract

Ridder DA, Bulashevska S, Chaitanya GV, Babu PP, Brors B, Eils R, Schneider A, Discovery of transcriptional programs in cerebral ischemia by in silico promoter analysis.
Schwaninger M.
Brain Res. 2009 May 26;1272:3-13.
Abstract

Hemichannels in cerebral ischemia.
Bargiotas P, Monyer H, Schwaninger M.
Curr Mol Med. 2009 Mar;9(2):186-94.
Abstract

Inta I, Weber D, Grundt C, Veltkamp R, Winteroll S, Auffarth GU, Bettendorf M, Lemmer B, Schwaninger M.
Correlation of soluble gp130 serum concentrations with arterial blood pressure.
J Hypertens. 2009 Mar;27(3):527-34.
Abstract

Ridder DA, Schwaninger M.
NF-kappaB signaling in cerebral ischemia.
Neuroscience. 2009 Feb 6;158(3):995-1006. Epub 2008 Jul 10.
Abstract


Muhammad S, Bierhaus A, Schwaninger M.
Reactive oxygen species in diabetes-induced vascular damage, stroke, and Alzheimer's disease.
J Alzheimers Dis. 2009;16(4):775-85.
Abstract

Sarnico I, Lanzillotta A, Boroni F, Benarese M, Alghisi M, Schwaninger M, Inta I, Battistin L, Spano P, Pizzi M.
NF-kappaB p50/RelA and c-Rel-containing dimers: opposite regulators of neuron vulnerability to ischaemia.
J Neurochem. 2009 Jan;108(2):475-85.
Abstract

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2008

Inta I, Frauenknecht K, Dörr H, Kohlhof P, Rabsilber T, Auffarth GU, Burkly L, Mittelbronn M, Hahm K, Sommer C, Schwaninger M.
Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke.
J Neurol Sci. 2008 Dec 15;275(1-2):117-20.
Abstract

Dominiak P.
Meilensteine in der Kardiologie
Dtsch Med Wochenschr. 2008 Dec;133 Suppl 8:S251.
Abstract


Muhammad S, Barakat W, Stoyanov S, Murikinati S, Yang H, Tracey KJ, Bendszus M, Rossetti G, Nawroth PP, Bierhaus A, Schwaninger M.
The HMGB1 receptor RAGE mediates ischemic brain damage.
J Neurosci. 2008 Nov 12;28(46):12023-31.
Abstract

Teschendorf P, Albertsmeier M, Vogel P, Padosch SA, Spöhr F, Kirschfink M, Schwaninger M, Böttiger BW, Popp E.
Neurological outcome and inflammation after cardiac arrest--effects of protein C in rats.
Resuscitation. 2008 Nov;79(2):316-24. Epub 2008 Jul 14.
Abstract

Imperial JS, Chen P, Sporning A, Terlau H, Daly NL, Craik DJ, Alewood PF, Olivera BM.
Tyrosine-rich conopeptides affect voltage-gated K+ channels.
J Biol Chem. 2008 Aug 22;283(34):23026-32.
Abstract

Lüders S, Schrader J, Berger J, Unger T, Zidek W, Böhm M, Middeke M, Motz W, Lübcke C, Gansz A, Brokamp L, Schmieder RE, Trenkwalder P, Haller H, Dominiak P; PHARAO Study Group.
The PHARAO study: prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril in patients with high-normal blood pressure: a prospective, randomized, controlled prevention trial of the German Hypertension League.
J Hypertens. 2008 Jul;26(7):1487-96.
Abstract

Koch M, Bonaventura K, Spillmann F, Dendorfer A, Schultheiss HP, Tschöpe C.
Attenuation of left ventricular dysfunction by an ACE inhibitor after myocardial infarction in a kininogen-deficient rat model.
Biol Chem. 2008 Jun;389(6):719-23.
Abstract

Jacobsen HC, Hakim SG, Lauer I, Dendorfer A, Wedel T, Sieg P.
Long-term results of autologous submandibular gland transfer for the surgical treatment of severe keratoconjunctivitis sicca.
J Craniomaxillofac Surg. 2008 Jun;36(4):227-33.
Abstract

Becker S, Terlau H.
Toxins from cone snails: properties, applications and biotechnological production.
Appl Microbiol Biotechnol. 2008 May;79(1):1-9.
Abstract

Heidbreder M, Naumann A, Tempel K, Dominiak P, Dendorfer A.
Remote vs. ischaemic preconditioning: the differential role of mitogen-activated protein kinase pathways.
Cardiovasc Res. 2008 Apr 1;78(1):108-15.
Abstract

Siegers CP, Syed Ali S, Tegtmeier M.
Aescin and troxerutin as a successful combination for the treatment of inner ear perfusion disturbances.
Phytomedicine. 2008 Mar;15(3):160-3.
Abstract

Voigt JP, Raasch W, Hörtnagl H, Bader M, Fink H, Jöhren O.
Changes in the brain serotonin satiety system in transgenic rats lacking brain angiotensinogen.
J Neuroendocrinol. 2008 Feb;20(2):182-7.
Abstract

Lang MF, Schneider A, Krüger C, Schmid R, Dziarski R, Schwaninger M.
Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-kappaB.
Neurosci Lett. 2008 Jan 10;430(2):138-41.
Abstract

Endres M, Engelhardt B, Koistinaho J, Lindvall O, Meairs S, Mohr JP, Planas A, Rothwell N, Schwaninger M, Schwab ME, Vivien D, Wieloch T, Dirnagl U.
Improving outcome after stroke: overcoming the translational roadblock.
Cerebrovasc Dis. 2008;25(3):268-78.
Abstract

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2007

Jöhren O, Dendorfer A, Dominiak P, Raasch W.
Gene expression of mineralocorticoid and glucocorticoid receptors in the limbic system is related to type-2 like diabetes in leptin-resistant rats.

Brain Res. 2007 Dec 12;1184:160-7.
Abstract

Zhang MM, Green BR, Catlin P, Fiedler B, Azam L, Chadwick A, Terlau H, McArthur JR, French RJ, Gulyas J, Rivier JE, Smith BJ, Norton RS, Olivera BM, Yoshikami D, Bulaj G.
Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.
J Biol Chem. 2007 Oct 19;282(42):30699-706.
Abstract

Müller H, Schweitzer N, Jöhren O, Dominiak P, Raasch W.
Angiotensin II stimulates the reactivity of the pituitary-adrenal axis in leptin-resistant Zucker rats, thereby influencing the glucose utilization.
Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E802-10.
Abstract

Jüttler E, Inta I, Eigler V, Herrmann O, Maegele I, Maser-Gluth C, Schwaninger M.
Neuronal NF-kappaB influences thermoregulation and survival in a sepsis model.
J Neuroimmunol. 2007 Sep;189(1-2):41-9.
Abstract

Leipold E, DeBie H, Zorn S, Borges A, Olivera BM, Terlau H, Heinemann SH.
muO conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2.
Channels (Austin). 2007 Jul-Aug;1(4):253-62.
Abstract

Schölzke MN, Schwaninger M.
Transcriptional regulation of neurogenesis: potential mechanisms in cerebral ischemia.
J Mol Med (Berl). 2007 Jun;85(6):577-88.
Abstract

Teichert RW, Jacobsen R, Terlau H, Yoshikami D, Olivera BM.
Discovery and characterization of the short kappaA-conotoxins: a novel subfamily of excitatory conotoxins.
Toxicon. 2007 Mar 1;49(3):318-28.
Abstract

Schaefer U, Kurz T, Bonnemeier H, Dendorfer A, Hartmann F, Schunkert H, Richardt G.
Intracoronary enalaprilat during angioplasty for acute myocardial infarction: alleviation of postischaemic neurohumoral and inflammatory stress?
J Intern Med. 2007 Feb;261(2):188-200.
Abstract

Heidbreder M, Qadri F, Jöhren O, Dendorfer A, Depping R, Fröhlich F, Wagner KF, Dominiak P.
Non-hypoxic induction of HIF-3alpha by 2-deoxy-D-glucose and insulin.
Biochem Biophys Res Commun. 2007 Jan 12;352(2):437-43.
Abstract

Schrader J, Kulschewski A, Dendorfer A.
Inhibition of the renin-angiotensin system and the prevention of stroke.
Am J Cardiovasc Drugs. 2007;7(1):25-37.
Abstract

Junius L, Brune T, Deters M, Schulze J, Siegers CP.
Glycine affects valproate hepatotoxicity.
Res Commun Mol Pathol Pharmacol. 2007-2008;120-121(1-6):93-104.

Abstract

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1998-2006

2006

Inta I, Paxian S, Maegele I, Zhang W, Pizzi M, Spano P, Sarnico I, Muhammad S, Herrmann O, Inta D, Baumann B, Liou HC, Schmid RM, Schwaninger M.
Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia.
J Neurosci. 2006 Dec 13;26(50):12896-903.
Abstract

Schwaninger M, Inta I, Herrmann O.
NF-kappaB signalling in cerebral ischaemia.
Biochem Soc Trans. 2006 Dec;34(Pt 6):1291-4.
Abstract

Martin JJ, Hausser I, Lyrer P, Busse O, Schwarz R, Schneider R, Brandt T, Kloss M, Schwaninger M, Engelter S, Grond-Ginsbach C.
Familial cervical artery dissections: clinical, morphologic, and genetic studies.
Stroke. 2006 Dec;37(12):2924-9. Epub 2006 Oct 19.
Abstract

Koch M, Spillmann F, Dendorfer A, Westermann D, Altmann C, Sahabi M, Linthout SV, Bader M, Walther T, Schultheiss HP, Tschöpe C.
Cardiac function and remodeling is attenuated in transgenic rats expressing the human kallikrein-1 gene after myocardial infarction.
Eur J Pharmacol. 2006 Nov 21;550(1-3):143-8. Epub 2006 Sep 7.
Abstract

Richardt D, Dendorfer A, Tölg R, Dominiak P, Richardt G.
Inhibition of nonexocytotic norepinephrine release by desipramine reduces myocardial infarction size.
Can J Physiol Pharmacol. 2006 Nov;84(11):1185-9.
Abstract

Jöhren O, Gremmels JA, Qadri F, Dendorfer A, Dominiak P.
Adrenal expression of orexin receptor subtypes is differentially regulated in experimental streptozotocin induced type-1 diabetes.
Peptides. 2006 Nov;27(11):2764-9. Epub 2006 Jul 5.
Abstract

Roesch-Ely D, Weiland S, Scheffel H, Schwaninger M, Hundemer HP, Kolter T, Weisbrod M.
Dopaminergic modulation of semantic priming in healthy volunteers.
Biol Psychiatry. 2006 Sep 15;60(6):604-11. Epub 2006 Apr 5.
Abstract

Diedler J, Rieger S, Koch A, Parthé-Peterhans S, Schwaninger M.
Bilateral facial palsy: Epstein-Barr virus, not Lyme disease.
Eur J Neurol. 2006 Sep;13(9):1029-30.
Abstract

Chourbaji S, Urani A, Inta I, Sanchis-Segura C, Brandwein C, Zink M, Schwaninger M, Gass P.
IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors.
Neurobiol Dis. 2006 Sep;23(3):587-94. Epub 2006 Jul 12.
Abstract

Veltkamp R, Sun L, Herrmann O, Wolferts G, Hagmann S, Siebing DA, Marti HH, Veltkamp C, Schwaninger M.
Oxygen therapy in permanent brain ischemia: potential and limitations.
Brain Res. 2006 Aug 30;1107(1):185-91. Epub 2006 Jul 10.
Abstract

Siegers CP, Schmidt M.
Akute Hepatitis durch Kava-Kava und Johanniskraut: immun-vermittelter Mechanismus?
Dtsch Med Wochenschr. 2006 Aug 25;131(34-35):1881-2; author reply 1882-3. German. No abstract available.
Abstract

Wiest T, Herrmann O, Stögbauer F, Grasshoff U, Enders H, Koch MJ, Grond-Ginsbach C, Schwaninger M.
Clinical and genetic variability of oculodentodigital dysplasia.
Clin Genet. 2006 Jul;70(1):71-2. No abstract available.
Abstract

Raasch W, Wittmershaus C, Dendorfer A, Voges I, Pahlke F, Dodt C, Dominiak P, Jöhren O.
Angiotensin II inhibition reduces stress sensitivity of hypothalamo-pituitary-adrenal axis in spontaneously hypertensive rats.
Endocrinology. 2006 Jul;147(7):3539-46. Epub 2006 Mar 30.
Abstract

Imperial JS, Bansal PS, Alewood PF, Daly NL, Craik DJ, Sporning A, Terlau H, Lopez-Vera E, Bandyopadhyay PK, Olivera BM.
A Novel Conotoxin Inhibitor of Kv1.6 Channel and nAChR Subtypes Defines a New Superfamily of Conotoxins.
Biochemistry. 2006 Jul 11;45(27):8331-8340
Abstract

Finol-Urdaneta RK, Struver N, Terlau H.
Molecular and Functional Differences between Heart mKv1.7 Channel Isoforms.
J Gen Physiol. 2006 Jul;128(1):133-45
Abstract

Bulaj G, Zhang MM, Green BR, Fiedler B, Layer RT, Wei S, Nielsen JS, Low SJ, Klein BD, Wagstaff JD, Chicoine L, Harty TP, Terlau H, Yoshikami D, Olivera BM.
Synthetic muO-Conotoxin MrVIB Blocks TTX-Resistant Sodium Channel Na(V)1.8 and Has a Long-Lasting Analgesic Activity.
Biochemistry. 2006 Jun 13;45(23):7404-14
Abstract

Jacobi C, Schwark C, Kress B, Hug A, Storch-Hagenlocher B, Schwaninger M.
Subarachnoid hemorrhage due to Borrelia burgdorferi-associated vasculitis.
Eur J Neurol. 2006 May;13(5):536-8.
Abstract

Longoni M, Grond-Ginsbach C, Grau AJ, Genius J, Debette S, Schwaninger M, Ferrarese C, Lichy C.
The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection.
Neurology. 2006 Apr 25;66(8):1273-5.
Abstract

Schumacher J, Puchakayala MR, Binkowski K, Eichler W, Dendorfer A, Klotz KF.
Effects of candesartan and enalaprilat on the organ-specific microvascular permeability during haemorrhagic shock in rats.
Br J Anaesth. 2006 Apr;96(4):437-43. Epub 2006 Feb 20.
Abstract

Veltkamp R, Bieber K, Wagner S, Beynon C, Siebing DA, Veltkamp C, Schwaninger M, Marti HH.
Hyperbaric oxygen reduces basal lamina degradation after transient focal cerebral ischemia in rats.
Brain Res. 2006 Mar 3;1076(1):231-7. Epub 2006 Feb 9.
Abstract

Schrader J, Lüders S, Kulschewski A, Hammersen F, Züchner C, Venneklaas U, Schrandt G, Schnieders M, Rangoonwala B, Berger J, Dominiak P, Zidek W; MARPLE Study Group.
Microalbuminuria and tubular proteinuria as risk predictors of cardiovascular morbidity and mortality in essential hypertension: final results of a prospective long-term study (MARPLE Study)*.
J Hypertens. 2006 Mar;24(3):541-8.

Bayrhuber M, Graf R, Ferber M, Zweckstetter M, Imperial J, Garrett JE, Olivera BM, Terlau H, Becker S.
Production of recombinant Conkunitzin-S1 in Escherichia coli.
Protein Expr Purif. 2006 Jun;47(2):640-4
Abstract

Drognitz O, Thorn D, Krüger T, Gatermann SG, Iven H, Bruch HP, Muhl E.
Release of vancomycin and teicoplanin from a plasticized and resorbable gelatin sponge: in vitro investigation of a new antibiotic delivery system with glycopeptides.
Infection. 2006 Feb;34(1):29-34.
Abstract

Zorn S, Leipold E, Hansel A, Bulaj G, Olivera BM, Terlau H, Heinemann SH
The muO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3.
FEBS Lett. 2006 Feb 20;580(5):1360-4
Abstract

Burgdorf C, Richardt G, Schütte F, Dendorfer A, Kurz T.
Impairment of presynaptic alpha2-adrenoceptor-regulated norepinephrine overflow in failing hearts from Zucker diabetic fatty rats.
J Cardiovasc Pharmacol. 2006 Feb;47(2):256-62.
Abstract

2005

Aller MI, Veale EL, Linden AM, Sandu C, Schwaninger M, Evans LJ, Korpi ER, Mathie A, Wisden W, Brickley SG.
Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons.
J Neurosci. 2005 Dec 7;25(49):11455-67.
Abstract

Herrmann O, Baumann B, de Lorenzi R, Muhammad S, Zhang W, Kleesiek J, Malfertheiner M, Köhrmann M, Potrovita I, Maegele I, Beyer C, Burke JR, Hasan MT, Bujard H, Wirth T, Pasparakis M, Schwaninger M.
IKK mediates ischemia-induced neuronal death.
Nat Med. 2005 Dec;11(12):1322-9. Epub 2005 Nov 13.
Abstract

Dendorfer A, Dominiak P, Tempel K, Raasch W.
Peripheral sympatholytic actions of four AT1 antagonists: are they relevant for long-term antihypertensive efficacy?
J Hypertens. 2005 Oct;23(10):1861-7.
Abstract

Häuser W, Sassmann A, Qadri F, Jöhren O, Dominiak P.
Expression of nitric oxide synthase isoforms in hypothalamo-pituitary-adrenal axis during the development of spontaneous hypertension in rats.
Brain Res Mol Brain Res. 2005 Aug 18;138(2):198-204.
Abstract

Raasch W, Dominiak P, Dendorfer A.
Angiotensin I-converting enzyme-dependent and neutral endopeptidase-dependent generation and degradation of angiotensin II contrarily modulate noradrenaline release: implications for vasopeptidase-inhibitor therapy?
J Hypertens. 2005 Aug;23(8):1597-604.
Abstract

Ringleb PA, Strittmatter EI, Loewer M, Hartmann M, Fiebach JB, Lichy C, Weber R, Jacobi C, Amendt K, Schwaninger M.
Cerebrovascular manifestations of Takayasu arteritis in Europe.
Rheumatology (Oxford). 2005 Aug;44(8):1012-5. Epub 2005 Apr 19.
Abstract

Veltkamp R, Siebing DA, Sun L, Heiland S, Bieber K, Marti HH, Nagel S, Schwab S, Schwaninger M.
Hyperbaric oxygen reduces blood-brain barrier damage and edema after transient focal cerebral ischemia.
Stroke. 2005 Aug;36(8):1679-83. Epub 2005 Jul 14.
Abstract

Di Napoli M, Schwaninger M, Cappelli R, Ceccarelli E, Di Gianfilippo G, Donati C, Emsley HC, Forconi S, Hopkins SJ, Masotti L, Muir KW, Paciucci A, Papa F, Roncacci S, Sander D, Sander K, Smith CJ, Stefanini A, Weber D.
Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members.
Stroke. 2005 Jun;36(6):1316-29. Epub 2005 May 5. Review.
Abstract

Schrader J, Lüders S, Kulschewski A, Hammersen F, Plate K, Berger J, Zidek W, Dominiak P, Diener HC; MOSES Study Group.
Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES).
Stroke. 2005 Jun;36(6):1218-26. Epub 2005 May 5.
Abstract

Wolfrum S, Nienstedt J, Heidbreder M, Schneider K, Dominiak P, Dendorfer A.
Calcitonin gene related peptide mediates cardioprotection by remote preconditioning.
Regul Pept. 2005 Apr 15;127(1-3):217-24.
Abstract

Roesch-Ely D, Scheffel H, Weiland S, Schwaninger M, Hundemer HP, Kolter T, Weisbrod M.
Differential dopaminergic modulation of executive control in healthy subjects.
Psychopharmacology (Berl). 2005 Apr;178(4):420-30. Epub 2004 Nov 18.
Abstract

Veltkamp R, Siebing DA, Heiland S, Schoenffeldt-Varas P, Veltkamp C, Schwaninger M, Schwab S.
Hyperbaric oxygen induces rapid protection against focal cerebral ischemia.
Brain Res. 2005 Mar 10;1037(1-2):134-8.
Abstract

Ringleb PA, Schwark C, Schwaninger M, Schellinger PD.
Efficacy and costs of secondary prevention with antiplatelets after ischaemic stroke.
Expert Opin Pharmacother. 2005 Mar;6(3):359-67. Review.
Abstract

Burgdorf C, Dendorfer A, Kurz T, Richardt G.
Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia.
Regul Pept. 2005 Feb 15;125(1-3):99-102.
Abstract

Kohl M, Wuerdemann I, Clemen J, Iven H, Katalinic A, Moeller JC.
Cisapride may improve feeding tolerance of preterm infants: a randomized placebo-controlled trial.
Biol Neonate. 2005;88(4):270-5. Epub 2005 Aug 18.
Abstract

Dendorfer A, Heidbreder M, Hellwig-Bürgel T, Jöhren O, Qadri F, Dominiak P.
Deferoxamine induces prolonged cardiac preconditioning via accumulation of oxygen radicals.
Free Radic Biol Med. 2005 Jan 1;38(1):117-24.
Abstract

Dendorfer A, Dominiak P, Schunkert H.
ACE inhibitors and angiotensin II receptor antagonists.
Handb Exp Pharmacol. 2005;(170):407-42. Review.
Abstract

Burgdorf C, Schütte F, Kurz T, Dendorfer A, Richardt G.
Adenylyl cyclase-dependent inhibition of myocardial norepinephrine release by presynaptic adenosine A1-receptors.
J Cardiovasc Pharmacol. 2005 Jan;45(1):1-3.
Abstract

Zhang W, Potrovita I, Tarabin V, Herrmann O, Beer V, Weih F, Schneider A, Schwaninger M.
Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemia.
J Cereb Blood Flow Metab. 2005 Jan;25(1):30-40.
Abstract

Adam BS, Pentz R, Siegers CP, Strubelt O, Tegtmeier M.
Troxerutin protects the isolated perfused rat liver from a possible lipid peroxidation by coumarin.
Phytomedicine. 2005 Jan;12(1-2):52-61.
Abstract

2004

Tschope C, Spillmann F, Rehfeld U, Koch M, Westermann D, Altmann C, Dendorfer A, Walther T, Bader M, Paul M, Schultheiss HP, Vetter R
Improvement of defective sarcoplasmic reticulum Ca2+ transport in diabetic heart of transgenic rats expressing the human kallikrein-1 gene.
FASEB J. 2004 Dec;18(15):1967-9
Abstract

Bierhaus A, Haslbeck KM, Humpert PM, Liliensiek B, Dehmer T, Morcos M, Sayed AA, Andrassy M, Schiekofer S, Schneider JG, Schulz JB, Heuss D, Neundörfer B, Dierl S, Huber J, Tritschler H, Schmidt AM, Schwaninger M, Haering HU, Schleicher E, Kasper M, Stern DM, Arnold B, Nawroth PP.
Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily.
J Clin Invest. 2004 Dec;114(12):1741-51.
Abstract

Li T, Qadri F, Moser A
Neuronal electrical high frequency stimulation modulates presynaptic GABAergic physiology.
Neurosci Lett. 2004 Nov 23;371(2-3):117-21
Abstract

Wolfrum S, Dendorfer A, Rikitake Y, Stalker TJ, Gong Y, Scalia R, Dominiak P, Liao JK
Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.
Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1842-7
Abstract

Kiprianova I, Schindowski K, von Bohlen und Halbach O, Krause S, Dono R, Schwaninger M, Unsicker K.
Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2.
Exp Neurol. 2004 Oct;189(2):252-60.
Abstract

Potrovita I, Zhang W, Burkly L, Hahm K, Lincecum J, Wang MZ, Maurer MH, Rossner M, Schneider A, Schwaninger M.
Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration.
J Neurosci. 2004 Sep 22;24(38):8237-44.
Abstract

Dvorak F, Martinez-Torres F, Sellner J, Haas J, Schellinger PD, Schwaninger M, Meyding-Lamadé UK.
Experimental herpes simplex virus encephalitis: a long-term study of interleukin-6 expression in mouse brain tissue.
Neurosci Lett. 2004 Sep 9;367(3):289-92.
Abstract

Raasch W, Dominiak P, Ziegler A, Dendorfer A
Reduction of vascular noradrenaline sensitivity by AT1 antagonists depends on functional sympathetic innervation.
Hypertension. 2004 Sep;44(3):346-51
Abstract

Wolfrum S, Dendorfer A, Schutt M, Weidtmann B, Heep A, Tempel K, Klein HH, Dominiak P, Richardt G
Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway.
J Cardiovasc Pharmacol. 2004 Sep;44(3):348-55
Abstract

Jüttler E, Potrovita I, Tarabin V, Prinz S, Dong-Si T, Fink G, Schwaninger M.
The cannabinoid dexanabinol is an inhibitor of the nuclear factor-kappa B (NF-kappa B).
Neuropharmacology. 2004 Sep;47(4):580-92.
Abstract

Jöhren O, Brüggemann N, Dominiak P
Orexins (hypocretins) and adrenal function.
Horm Metab Res. 2004 Jun;36(6):370-5
Abstract

Jöhren O, Dendorfer A, Dominiak P
Cardiovascular and renal function of angiotensin II type-2 receptors.
Cardiovasc Res. 2004 Jun;62(3):460-7
Abstract

Tarabin V, Schwaninger M.
The role of NF-kappaB in 6-hydroxydopamine- and TNFalpha-induced apoptosis of PC12 cells.
Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):563-9.
Abstract

Burgdorf C, Dendorfer A, Kurz T, Schömig E, Stölting I, Schütte F, Richardt G
Role of neuronal KATP channels and extraneuronal monoamine transporter on norepinephrine overflow in a model of myocardial low flow ischemia.
J Pharmacol Exp Ther. 2004 Apr;309(1):42-8
Abstract

Weber MA, Jacobi C, Storch-Hagenlocher B, Schwaninger M, Schramm P.
Akuter Querschnitt
Radiologe. 2004 Apr;44(4):376-9.
Abstract

Nurmi A, Lindsberg PJ, Koistinaho M, Zhang W, Juettler E, Karjalainen-Lindsberg ML, Weih F, Frank N, Schwaninger M, Koistinaho J.
Nuclear factor-kappaB contributes to infarction after permanent focal ischemia.
Stroke. 2004 Apr;35(4):987-91.
Abstract

Qadri F, Stark E, Häuser W, Jöhren O, Dendorfer A, Dominiak P
Expression of kinin receptor mRNA in the HPA axis of type 1 and type 2 diabetic rats.
Int Immunopharmacol. 2004 Apr;4(4):571-6
Abstract

Heusser K, Vitkovsky J, Raasch W, Schmieder RE, Schobel HP
Reply to heinz rupp's letter to the editor concerning our article "elevation of sympathetic activity by eprosartan in young male subjects" (Am J Hypertens 2003;16(8):658-664).
Am J Hypertens. 2004 Mar;17(3):281-3
Abstract

Raasch W, Jöhren O, Schwartz S, Gieselberg A, Dominiak P
Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR.
J Hypertens. 2004 Mar;22(3):611-8
Abstract

Schneider A, Laage R, von Ahsen O, Fischer A, Rossner M, Scheek S, Grünewald S, Kuner R, Weber D, Krüger C, Klaussner B, Götz B, Hiemisch H, Newrzella D, Martin-Villalba A, Bach A, Schwaninger M.
Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4.
J Neurochem. 2004 Mar;88(5):1114-26.
Abstract

Schneider A, Fischer A, Weber D, von Ahsen O, Scheek S, Krüger C, Rossner M, Klaussner B, Faucheron N, Kammandel B, Goetz B, Herrmann O, Bach A, Schwaninger M.
Restriction-mediated differential display (RMDD) identifies pip92 as a pro-apoptotic gene product induced during focal cerebral ischemia.
J Cereb Blood Flow Metab. 2004 Feb;24(2):224-36.
Abstract

Veltkamp R, Veltkamp C, Hartmann M, Schönffeldt-Varas P, Schwaninger M.
Symptomatische Dissektion der Arteria carotis interna. Eine seltene Manifestation der autosomal-dominanten polyzystischen Nierenerkrankung?
Nervenarzt. 2004 Feb;75(2):149-52.
Abstract

Schwaninger M, Ringleb P, Hacke W.
Design issues in selected recent or ongoing stroke trials.
Ernst Schering Res Found Workshop. 2004;(47):205-15.
Abstract

2003

Raasch W, Jungbluth B, Schäfer U, Häuser W, Dominiak P.
Norepinephrine release is reduced by I(1)-receptors in addition to alpha(2)-adrenoceptors.
Ann N Y Acad Sci. 2003 Dec;1009:270-3.
Abstract

Schölzke MN, Potrovita I, Subramaniam S, Prinz S, Schwaninger M.
Glutamate activates NF-kappaB through calpain in neurons.
Eur J Neurosci. 2003 Dec;18(12):3305-10. Erratum in: Eur J Neurosci. 2004 Sep;20(5):1424.
Abstract

Meisel F, Jacobi C, Kollmar R, Hug A, Schwaninger M, Schwab S.
Akute Meningitis nach transrektaler Prostatapunktion.
Urologe A. 2003 Dec;42(12):1611-5.
Abstract

Dominiak P, Häuser W.
Äquivalenzdosen der in Deutschland verfügbaren AT1-Rezeptor-Antagonisten.
Dtsch Med Wochenschr. 2003 Oct 31;128(44):2315-8. Erratum in: Dtsch Med Wochenschr. 2004 Mar 19;129(12):646.
Abstract

Butterweck V, Prinz S, Schwaninger M.
The role of interleukin-6 in stress-induced hyperthermia and emotional behaviour in mice.
Behav Brain Res. 2003 Sep 15;144(1-2):49-56.
Abstract

Qadri F, Arens T, Schwarz EC, Häuser W, Dendorfer A, Dominiak P.
Brain nitric oxide synthase activity in spontaneously hypertensive rats during the development of hypertension.
J Hypertens. 2003 Sep;21(9):1687-94.
Abstract

Heidbreder M, Fröhlich F, Jöhren O, Dendorfer A, Qadri F, Dominiak P.
Hypoxia rapidly activates HIF-3alpha mRNA expression.
FASEB J. 2003 Aug;17(11):1541-3.
Abstract

Acalovschi D, Wiest T, Hartmann M, Farahmi M, Mansmann U, Auffarth GU, Grau AJ, Green FR, Grond-Ginsbach C, Schwaninger M.
Multiple levels of regulation of the interleukin-6 system in stroke.
Stroke. 2003 Aug;34(8):1864-9.
Abstract

Schrader J, Lüders S, Kulschewski A, Berger J, Zidek W, Treib J, Einhäupl K, Diener HC, Dominiak P; Acute Candesartan Cilexetil Therapy in Stroke Survivors Study Group.
The ACCESS Study: evaluation of Acute Candesartan Cilexetil Therapy in Stroke Survivors.
Stroke. 2003 Jul;34(7):1699-703.
Abstract

Grau AJ, Schwaninger M, Goebel HH, Beck M.
Morbus Fabry. Eine lysosomale Stoffwechselerkrankung mit neuen therapeutischen Möglichkeiten.
Nervenarzt. 2003 Jun;74(6):489-96.
Abstract

Oltmanns KM, Deininger E, Wellhoener P, Schultes B, Kern W, Marx E, Dominiak P, Born J, Fehm HL, Peters A.
Influence of captopril on symptomatic and hormonal responses to hypoglycaemia in humans.
Br J Clin Pharmacol. 2003 Apr;55(4):347-53.
Abstract

Jöhren O, Brüggemann N, Dendorfer A, Dominiak P.
Gonadal steroids differentially regulate the messenger ribonucleic acid expression of pituitary orexin type 1 receptors and adrenal orexin type 2 receptors.
Endocrinology. 2003 Apr;144(4):1219-25.
Abstract

Jöhren O, Golsch C, Dendorfer A, Qadri F, Häuser W, Dominiak P.
Differential expression of AT1 receptors in the pituitary and adrenal gland of SHR and WKY.
Hypertension. 2003 Apr;41(4):984-90.
Abstract

Herrmann O, Tarabin V, Suzuki S, Attigah N, Coserea I, Schneider A, Vogel J, Prinz S, Schwab S, Monyer H, Brombacher F, Schwaninger M.
Regulation of body temperature and neuroprotection by endogenous interleukin-6 in cerebral ischemia.
J Cereb Blood Flow Metab. 2003 Apr;23(4):406-15.
Abstract

Schäbitz WR, Glatz K, Schuhan C, Sommer C, Berger C, Schwaninger M, Hartmann M, Hilmar Goebel H, Meinck HM.
Severe forward flexion of the trunk in Parkinson's disease: focal myopathy of the paraspinal muscles mimicking camptocormia.
Mov Disord. 2003 Apr;18(4):408-14.
Abstract

Qadri F, Schwartz EC, Häuser W, Jöhren O, Müller-Esterl W, Dominiak P.
Kinin B2 receptor localization and expression in the hypothalamo-pituitary-adrenal axis of spontaneously hypertensive rats.
Int Immunopharmacol. 2003 Mar;3(3):285-92.
Abstract

Raasch W, Jungbluth B, Schäfer U, Häuser W, Dominiak P.
Modification of noradrenaline release in pithed spontaneously hypertensive rats by I1-binding sites in addition to alpha2-adrenoceptors.
J Pharmacol Exp Ther. 2003 Mar;304(3):1063-71.
Abstract

Schäbitz WR, Kollmar R, Schwaninger M, Juettler E, Bardutzky J, Schölzke MN, Sommer C, Schwab S.
Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia.
Stroke. 2003 Mar;34(3):745-51.
Abstract

Bierhaus A, Wolf J, Andrassy M, Rohleder N, Humpert PM, Petrov D, Ferstl R, von Eynatten M, Wendt T, Rudofsky G, Joswig M, Morcos M, Schwaninger M, McEwen B, Kirschbaum C, Nawroth PP.
A mechanism converting psychosocial stress into mononuclear cell activation.
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1920-5.
Abstract

Dendorfer A, Folkers V, Klinger M, Wolfrum S, Dominiak P.
Inhibition of kinin breakdown prolongs retention and action of bradykinin in a myocardial B2 receptor compartment.
Br J Pharmacol. 2003 Jan;138(2):310-6.
Abstract

Dominiak P.
Stellenwert der ACE-Hemmer in der Hochdrucktherapie: Seit langem etabliert!
Pharm Unserer Zeit. 2003;32(1):24-9.
Abstract

2002

Kollmar R, Schellinger PD, Bardutzky J, Meisel F, Schwaninger M.
Myxödemkoma als seltene Differenzialdiagnose einer schweren Bewusstseinsstörung.
Nervenarzt. 2002 Dec;73(12):1183-5
Abstract

Heller R, Grau AJ, Schäbitz WR, Schwaninger M.
Zerebrotendinöse Xanthomatose. Eine behandelbare Stoffwechselerkrankung.
Nervenarzt. 2002 Dec;73(12):1160-6
Abstract

Raasch W, Bartels T, Schwartz C, Häuser W, Rütten H, Dominiak P
Regression of ventricular and vascular hypertrophy: are there differences between structurally different angiotensin-converting enzyme inhibitors?
J Hypertens. 2002 Dec;20(12):2495-504
Abstract

Bostelmann HC, Bödeker RH, Dames W, Henneicke-von Zepelin HH, Siegers CP, Stammwitz U
Immunmodulation durch pflanzliche Wirkstoffe. Doppelblindstudie an einer medizinischen Universitätsklinik am Adjuvansmodell zur Hepatitis-B-Impfung.
[Immunomodulation by herbal agents. A double-blind study in a medical university hospital involving a hepatitis B vaccine adjuvant model.]
Fortschr Med Orig. 2002 Dec 5;120(4):119-23
Abstract

Thümen A, Qadri F, Sarkar R, Moser A
GBR-12909 effect on dopamine outflow depends on phosphorylation in the caudate nucleus of the rat.
Synapse. 2002 Nov;46(2):72-8
Abstract

Wagner S, Kalb P, Lukosava M, Hilgenfeldt U, Schwaninger M.
Activation of the tissue kallikrein-kinin system in stroke.
J Neurol Sci. 2002 Oct 15;202(1-2):75-6
Abstract

Richardt D, Wolfrum S, Büttner C, Schäfer U, Dendorfer A, Kurz T, Richardt G
Effect of ACE-inhibitor ramiprilat and AT1-receptor antagonist candesartan on cardiac norepinephrine release: comparison between ischemic and nonischemic conditions.
J Cardiovasc Pharmacol. 2002 Oct;40(4):641-6
Abstract

Gutschalk A, Kollmar R, Mohr A, Henze M, Ille N, Schwaninger M, Hartmann M, Hähnel S, Haberkorn U, Rupp A, Meyding-Lamade U.
Multimodal functional imaging of prolonged neurological deficits in a patient suffering from familial hemiplegic migraine.
Neurosci Lett. 2002 Oct 31;332(2):115-8
Abstract

Increased angiotensin II AT(1) receptor expression in paraventricular nucleus and hypothalamic-pituitary-adrenal axis stimulation in AT(2) receptor gene disrupted mice.
Armando I, Terrón JA, Falcón-Neri A, Takeshi I, Häuser W, Inagami T, Saavedra JM.
Neuroendocrinology. 2002 Sep;76(3):137-47.
Abstract

Tom B, Dendorfer A, de Vries R, Saxena PR, Jan Danser AH
Bradykinin potentiation by ACE inhibitors: a matter of metabolism.
Br J Pharmacol. 2002 Sep;137(2):276-84
Abstract

Dendorfer A, Thornagel A, Raasch W, Grisk O, Tempel K, Dominiak P
Angiotensin II induces catecholamine release by direct ganglionic excitation.
Hypertension. 2002 Sep;40(3):348-54
Abstract

Dominiak P, Zidek W
German Hypertension League on the LIFE Study. New evaluation of AT1 receptor antagonists.
MMW Fortschr Med. 2002 Sep 19;144(38):47
Abstract

Roesch-Ely D, Van Einsiedel R, Kathöfer S, Schwaninger M, Weisbrod M.
Myocarditis with quetiapine.
Am J Psychiatry. 2002 Sep;159(9):1607-8
Abstract

Schäfer U, Kurz T, Jain D, Hartmann F, Dendorfer A, Tölg R, Raasch W, Dominiak P, Katus H, Richardt G
Impaired coronary flow and left ventricular dysfunction after mechanical recanalization in acute myocardial infarction: role of neurohumoral activation?
Basic Res Cardiol. 2002 Sep;97(5):399-408
Abstract

Schwaninger M, Haehnel S, Hess K, Fohr B, Nawroth P, Hacke W.
Cerebellar ataxia after repeated hypoglycemia.
Eur J Neurol. 2002 Sep;9(5):544-5
Abstract

Schäbitz WR, Giuffrida A, Berger C, Aschoff A, Schwaninger M, Schwab S, Piomelli D.
Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study.
Stroke. 2002 Aug;33(8):2112-4
Abstract

Dorges V, Wenzel V, Dix S, Kuhl A, Schumann T, Huppe M, Iven H, Gerlach K
The effect of midazolam on stress levels during simulated emergency medical service transport: a placebo-controlled, dose-response study.
Anesth Analg. 2002 Aug;95(2):417-22
Abstract

Hecker H, Johannisson R, Koch E, Siegers CP
In vitro evaluation of the cytotoxic potential of alkylphenols from Ginkgo biloba L.
Toxicology. 2002 Aug 15;177(2-3):167-77
Abstract

Walther T, Siems WE, Hauke D, Spillmann F, Dendorfer A, Krause W, Schultheiss HP, Tschöpe C
AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats.
FASEB J. 2002 Aug;16(10):1237-41
Abstract

Wolfrum S, Schneider K, Heidbreder M, Nienstedt J, Dominiak P, Dendorfer A
Remote preconditioning protects the heart by activating myocardial PKCepsilon-isoform.
Cardiovasc Res. 2002 Aug 15;55(3):583-9
Abstract

Dominiak P
Pharmacotherapeutic strategy in heart failure.
Clin Nephrol. 2002 Jul;58 Suppl 1:S2-6
Abstract

Dendorfer A, Raasch W, Tempel K, Dominiak P
Comparison of the vascular and antiadrenergic activities of four angiotensin II type 1 antagonists in the pithed rat.
J Hypertens. 2002 Jun;20(6):1151-6
Abstract

Jöhren O, Neidert SJ, Kummer M, Dominiak P
Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus.
Peptides. 2002 Jun;23(6):1177-80
Abstract

Jüttler E, Tarabin V, Schwaninger M.
Interleukin-6 (IL-6): a possible neuromodulator induced by neuronal activity.
Neuroscientist. 2002 Jun;8(3):268-75
Abstract

Struck J, Muck P, Trübger D, Handrock R, Weidinger G, Dendorfer A, Dodt C
Effects of selective angiotensin II receptor blockade on sympathetic nerve activity in primary hypertensive subjects.
J Hypertens. 2002 Jun;20(6):1143-9
Abstract

Qadri F, Häuser W, Jöhren O, Dominiak P
Kinin B1 and B2 receptor mRNA expression in the hypothalamus of spontaneously hypertensive rats.
Can J Physiol Pharmacol. 2002 Apr;80(4):258-63
Abstract

Guenter SG, Iven H, Boos C, Bruch HP, Muhl E
Pharmacokinetics of levofloxacin during continuous venovenous hemodiafiltration and continuous venovenous hemofiltration in critically ill patients
Pharmacotherapy. 2002 Feb;22(2):175-83
Abstract

Raasch W, Bartels T, Gieselberg A, Dendorfer A, Dominiak P
Angiotensin I-converting enzyme inhibition increases cardiac catecholamine content and reduces monoamine oxidase activity via an angiotensin type 1 receptor-mediated mechanism.
J Pharmacol Exp Ther. 2002 Feb;300(2):428-34
Abstract

Raasch W, Schäfer U, Qadri F, Dominiak P
Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction.
Br J Pharmacol. 2002 Feb;135(3):663-72
Abstract

Dominiak P, Dendorfer A, Raasch W
Therapierelevante Unterschiede bei Betablockern und ACE-Hemmern. Innovation oder Plagiat?
MMW Fortschr Med. 2002 Jan 17;144(1-2):50-4
Abstract

Fielitz J, Dendorfer A, Pregla R, Ehler E, Zurbrugg HR, Bartunek J, Hetzer R, Regitz-Zagrosek V
Neutral endopeptidase is activated in cardiomyocytes in human aortic valve stenosis and heart failure.
Circulation. 2002 Jan 22;105(3):286-9
Abstract

Thümen A, Behnecke A, Qadri F, Bäuml E, Moser A
N-methyl-norsalsolinol, a putative dopaminergic neurotoxin, passes through the blood-brain barrier in vivo.
Neuroreport. 2002 Jan 21;13(1):25-8
Abstract

2001

Bierhaus A, Schiekofer S, Schwaninger M, Andrassy M, Humpert PM, Chen J, Hong M, Luther T, Henle T, Klöting I, Morcos M, Hofmann M, Tritschler H, Weigle B, Kasper M, Smith M, Perry G, Schmidt AM, Stern DM, Häring HU, Schleicher E, Nawroth PP.
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.
Diabetes. 2001 Dec;50(12):2792-808
Abstract

Dedio J, Wiemer G, Rütten H, Dendorfer A, Schölkens B.A., Müller-Esterl W, Wohlfahrt P
Tissue kallikrein KLK1 is expressed de novo in endothelial cells and mediates relaxation of human umbilical veins.
Biol Chem. 2001 Oct;382(10):1483-90
Abstract

Deininger E, Oltmanns KM, Wellhöner P, Frühwald-Schultes B, Kern W, Heuer B, Dominiak P, Born J, Fehm HL, Peters A
Losartan attenuates symptomatic and hormonal responses to hypoglycemia in humans.
Clin Pharmacol Ther 70:362-9 (2001)
Abstract

Dendorfer A, Reißmann S, Wolfrum S, Raasch W, Dominiak P
Potentiation of kinin analogues by ramiprilat is exclusively related to their degradation.
Hypertension 38:142-6 (2001)
Abstract

Dendorfer A, Wolfrum S, Wagemann M, Qadri F, Dominiak P
Pathways of bradykinin degradation in blood and plasma of normotensive and hypertensive rats.
Am J Physiol Heart Circ Physiol 280:H2182-8 (2001)
Abstract

Jöhren O, Neidert SJ, Kummer M, Dendorfer A, Dominiak P
Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats.
Endocrinology 142:3324-31 (2001)
Abstract

Kummer M, Neidert S, Jöhren O, Dominiak P
Orexin (hypocretin) gene expression in rat ependymal cells.
NeuroReport 12: 2117-20 (2001)
Abstract

Kurz T, Schäfer U, Dendorfer A, Hartmann F, Raasch W, Tölg R, Remppis A, Giannitsis E, Dominiak P, Katus H.A, Richardt G
Effects of intracoronary low-dose enalaprilat as an adjunct to primary PTCA in acute mycardial infarction.
Am J Cardiol. 2001 Dec 15;88(12):1351-7
Abstract

Muhl E, Bundesen J, Iven H, Bruch HP
Measurement and Calculation of the Extracorporeal Elimination of Vancomycin During Continuous Venovenous Hemodiafiltration and Continuous Venovenous Hemofiltration in Critically I11 Patients.
J Intensive Care Med. 2001;16:222-30

Qadri F, Arens T, Schwartz Eike C, Häuser W, Dominiak P
Angiotensin-Converting Enzyme Inhibitors and AT1-Receptor Antagonist Restore Nitric Oxide Synthase (NOS) Activity and Neuronal NOS Expression in the Adrenal Glands of Spontaneously Hypertensive Rats
Jpn J Pharmacol 85:365-9 (2001)
Abstract

Raasch W, Betge S, Dendorfer A, Bartels T, Dominiak P
Angiotensin converting enzyme inhibition improves cardiac neuronal uptake of noradrenaline in spontaneously hypertensive rats.
J Hypertens 19:1827-33 (2001)
Abstract

Raasch W, Schäfer U, Chun J, Dominiak P
Biological significance of agmatine, an endogenous ligand at imidazoline binding sites.
Br J Pharmacol 133:755-80 (2001)
Abstract

Saavedra JM, Armando I, Terron JA, Falcon-Neri A, Jöhren O, Häuser W, Inagami T
Increased AT(1) receptors in adrenal gland of AT(2) receptor gene-disrupted mice.
Regul Pept 102:41-7 (2001)
Abstract

Saavedra JM, Häuser W, Ciuffo G, Egidy G, Hoe KL, Jöhren O, Sembonmatsu T, Inagami T, Armando I.
Increased AT(1) receptor expression and mRNA in kidney glomeruli of AT(2) receptor gene-disrupted mice.
Am J Physiol Renal Physiol 280:F71-8 (2001)
Abstract

Sakowitz OW, Wolfrum S, Sarrafzadeh AS, Stover JF, Dreier JP, Dendorfer A, Benndorf G, Lanksch WR, Unterberg AW
Relation of celebral energy metabolism and extracellular nitrite/nitrate concentration in patients following aneurysmal subarachnoid hemorrhage.
J Cereb Blood Flow Metab 21:1067-76 (2001)
Abstract

Teismann P, Schwaninger M, Weih F, Ferger B.
Nuclear factor-kappaB activation is not involved in a MPTP model of Parkinson's disease.
Neuroreport. 2001 Apr 17;12(5):1049-53
Abstract

Wethmar U, Raasch W, Dendorfer A, Dominiak P
Interactions of ligands at angiotensin II-receptors and imidazoline receptors.
Jpn J Pharmacol 85:167-74 (2001)
Abstract

Weyer N, Kröplin T, Fricke L, Iven H
Human thiopurine-s-methyltransferaseactivity in uremia and after renal transplantation.
Eur J Clin Pharmacol 57:129-36 (2001)
Abstract

Wilhelm KP, Biel S, Siegers CP
Role of flavonoids in controlling the phototoxicity of Hypericum perforatum extracts.
Phytomedicine 8:306-9 (2001)
Abstract

Wilhelm KP, Böttjer B, Siegers CP
Quantitative assessment of primary skin irritants in vitro in a cytotoxicity model: comparison with in vivo human irritation tests.
Br J Dermatol. 2001 Nov;145(5):709-15
Abstract

Wolfrum S, Richard G, Dominiak P, Katus HA, Dendorfer A
Apstatin, a selective inhibitor of aminopeptidase P, reduces myocardial infarct size by a kinin-dependent pathway.
Brit J Pharmacol 134:374-4 (2001)
Abstract

2000

Sallmann S, Jüttler E, Prinz S, Petersen N, Knopf U, Weiser T, Schwaninger M.
Induction of interleukin-6 by depolarization of neurons.
J Neurosci. 2000 Dec 1;20(23):8637-42
Abstract

Schwaninger M, Ringleb P, Annecke A, Winter R, Kohl B, Werle E, Fiehn W, Rieser PA, Walter-Sack I.
Elevated plasma concentrations of lipoprotein(a) in medicated epileptic patients.
J Neurol. 2000 Sep;247(9):687-90
Abstract

Schäbitz WR, Sommer C, Zoder W, Kiessling M, Schwaninger M, Schwab S.
Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia.
Stroke. 2000 Sep;31(9):2212-7
Abstract

Raasch W, Slotty C, Dominiak P.
In vitro and in vivo long term release of apomorphine from polymer matrices.
Jpn J Pharmacol. 2000 Sep;84(1):36-43
Abstract

Raasch W, Chun KRJ, Dendorfer A, Dominiak P.
Positive inotropic effects of imidazoline derivatives are not mediated via imidazoline binding sites but alpha1-adrenergic receptors.
Jpn J Pharmacol. 2000 Sep;84(1):1-6.
Abstract

Dendorfer A, Dominiak P.
Vasopeptidase inhibition as a new concept in antihypertensive therapy.
Kidney Blood Press Res. 2000;23(3-5):178-9
Abstract

Schwaninger M, Petersen N, Prinz S, Sallmann S, Neher M, Spranger M.
Adenosine-induced expression of interleukin-6 in astrocytes through protein kinase A and NF-IL-6.
Glia. 2000 Jul;31(1):51-8
Abstract

Dendorfer A, Wolfrum S, Schäfer U, Stewart JM, Inamura N, Dominiak P.
Potentiation of the vascular response to kinins by inhibition of myocardial kininases.
Hypertension. 2000 Jan;35(1 Pt 1):32-7
Abstract

Tonelli L, Jöhren O, Hoe KL, Häuser W, Saavedra JM.
Gerbil angiotensin II AT1 receptors are highly expressed in the hippocampus and cerebral cortex during postnatal development.
Neuroscience. 2000;95(4):981-91.
Abstract

1999

Schwaninger M, Sallmann S, Petersen N, Schneider A, Prinz S, Libermann TA, Spranger M.
Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear factor-kappaB.J Neurochem. 1999 Oct;73(4):1461-6.

Abstract

Siegers CP, Andresen S, Keogh JP.
Does cimetidine improve prospects for cancer patients?. A reappraisal of the evidence to date.
Digestion. 1999 Sep-Oct;60(5):415-21. Review.
Abstract

Qadri F, Bäurle L, Häuser W, Rascher W, Dominiak P.
Centrally bradykinin B2-receptor-induced hypertensive and positive chronotropic effects are mediated via activation of the sympathetic nervous system.
J Hypertens. 1999 Sep;17(9):1265-71.
Abstract

Kallfelz HC, Kaemmerer H, Bönner G, Dominiak P, Zimmermann R, vom Dahl J.
Progress report of the "Clinical Pharmacology" Study Group 10 March 1998 to 10 March 1999.
Z Kardiol. 1999 Aug;88(8):607-8. German. No abstract available.
Abstract

Raasch W, Muhle H, Dominiak P.
Modulation of MAO activity by imidazoline and guanidine derivatives.
Ann N Y Acad Sci. 1999 Jun 21;881:313-31.
Abstract

Schäfer U, Raasch W, Qadri F, Chun J, Dominiak P.
Effects of agmatine on the cardiovascular system of spontaneously hypertensive rats.
Ann N Y Acad Sci. 1999 Jun 21;881:97-101. No abstract available.
Abstract

Kröplin T, Fischer C, Iven H.
Inhibition of thiopurine S-methyltransferase activity by impurities in commercially available substrates: a factor for differing results of TPMT measurements.
Eur J Clin Pharmacol. 1999 Jun;55(4):285-91.
Abstract

Siemann G, Blume R, Grapentin D, Oetjen E, Schwaninger M, Knepel W.
Inhibition of cyclic AMP response element-binding protein/cyclic AMP response element-mediated transcription by the immunosuppressive drugs cyclosporin A and FK506 depends on the promoter context.
Mol Pharmacol. 1999 Jun;55(6):1094-100.
Abstract

Wirbelauer C, Iven H, Bastian C, Laqua H.
Systemic levels of lidocaine after intracameral injection during cataract surgery.
J Cataract Refract Surg. 1999 May;25(5):648-51.
Abstract

Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M.
NF-kappaB is activated and promotes cell death in focal cerebral ischemia.
Nat Med. 1999 May;5(5):554-9.
Abstract

Strubelt O, Deters M, Pentz R, Siegers CP, Younes M.
The toxic and metabolic effects of 23 aliphatic alcohols in the isolated perfused rat liver.
Toxicol Sci. 1999 May;49(1):133-42.
Abstract

Hilbers U, Peters J, Bornstein SR, Correa FM, Jöhren O, Saavedra JM, Ehrhart-Bornstein M.
Local renin-angiotensin system is involved in K+-induced aldosterone secretion from human adrenocortical NCI-H295 cells.
Hypertension. 1999 Apr;33(4):1025-30.
Abstract

Dendorfer A, Wolfrum S, Dominiak P.
Pharmacology and cardiovascular implications of the kinin-kallikrein system.
Jpn J Pharmacol. 1999 Apr;79(4):403-26. Review.
Abstract

Schwaninger M, Ringleb P, Winter R, Kohl B, Fiehn W, Rieser PA, Walter-Sack I.
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
Epilepsia. 1999 Mar;40(3):345-50.
Abstract

Möller JC, Austing A, Püst B, Kohl M, Reiss I, Iven H, Gortner L.
Vergleichende Untersuchung zur Wirkung von Theophyllin und Doxapram bei Apnoen.
Klin Padiatr. 1999 Mar-Apr;211(2):86-91. German.
Abstract


Siegers CP, Röbke A, Pentz R.
Effects of garlic preparations on superoxide production by phorbol ester activated granulocytes.
Phytomedicine. 1999 Mar;6(1):13-6.
Abstract

Siegers CP, Steffen B, Röbke A, Pentz R.
The effects of garlic preparations against human tumor cell proliferation.
Phytomedicine. 1999 Mar;6(1):7-11.
Abstract

Dominiak P.
How can we lower blood pressure safely and effectively?.
Fortschr Med. 1999 Feb 28;117(6):32-3.
Abstract

Fürstenau U, Schwaninger M, Blume R, Jendrusch EM, Knepel W.
Characterization of a novel calcium response element in the glucagon gene.
J Biol Chem. 1999 Feb 26;274(9):5851-60.
Abstract

Häuser W, Jöhren O, de Oliveira AM, Shibata S, Saavedra JM.
Ischemia-induced neuronal cell loss is associated with loss of atypical angiotensin type-1 receptor expression in the gerbil hippocampal formation.
Brain Res. 1999 Jan 30;817(1-2):34-44.
Abstract

Wolfrum S, Dendorfer A, Dominiak P.
Identification of kallidin degrading enzymes in the isolated perfused rat heart.
Jpn J Pharmacol. 1999 Jan;79(1):117-20.
Abstract

Derad I, Dendorfer A, Dominiak P, Fehm HL, Born J.
Angiotensin converting enzyme inhibition by captopril influences cardiac work in healthy hearts.
Am J Hypertens. 1998 Nov;11(11 Pt 1):1290-6.
Abstract

Schwaninger M, Weisbrod M, Schwab S, Schröder M, Hacke W.
Hypothermia induced by atypical neuroleptics.
Clin Neuropharmacol. 1998 Nov-Dec;21(6):344-6.
Abstract

Jöhren O, Häuser W, Saavedra JM.
Chemical lesion of the inferior olive reduces [125I]sarcosine1-angiotensin II binding to AT2 receptors in the cerebellar cortex of young rats.
Brain Res. 1998 May 18;793(1-2):176-86.
Abstract

Nishimura Y, Xu T, Jöhren O, Häuser W, Saavedra JM.
The angiotensin AT1 receptor antagonist CV-11974 regulates cerebral blood flow and brain angiotensin AT1 receptor expression.
Basic Res Cardiol. 1998;93 Suppl 2:63-8.
Abstract

Dendorfer A, Raasch W, Tempel K, Dominiak P.
Interactions between the renin-angiotensin system (RAS) and the sympathetic system.
Basic Res Cardiol. 1998;93 Suppl 2:24-9.
Abstract