Introduction

We investigate cellular mechanisms underlying cerebral small vessel diseases. By using sophisticated genetic, viral and imaging techniques like calcium imaging and super resolution (STED) we aim to understand the function of cerebral endothelial cells in health and disease.

We are looking for a highly motivated candidate for the following PhD project: Endothelial necroptosis in cerebral small vessel disease

Project Description

The project is funded by the German Research Foundation (DFG) and deals with the role endothelial necroptosis in small vessel disease. We want to characterize the role of endothelial necroptosis and its regulation by molecular and cellular factors in the brain. The project will employ in vivo techniques.

Experimental Methods

• Working with genetically modified mice
• State-of-the-art STED and confocal microscopy
• Immunohistochemical and protein amount analyses
• Image acquisition and analysis
• Cell culture
• Gene expression analyses
• Single cell RNA sequencing and data analysis

Our Offer

• 3-year employment contract, salaries according to German civil service tariff (TV-L 13, 65%)
• Excellent work environment at the Center of Brain, Behavior and Metabolism (CBBM) with state-of-the-art lab facilities incl. animal facility, MRI scanner, metabolic core unit, LC-MS, STED and 2-photon microscopy
• Comprehensive academic support, e.g. soft skills training, funding for research stays abroad and international conferences
• International laboratory with inclusive working environment, colleagues with vast backgrounds and expertise
• Working in the city of Lübeck among many UNESCO World Heritage sites and directly on the Baltic Sea coastline and part of the Metropolitan area of Hamburg, Germany's second largest city and home to a wide range of cultural and leisure attractions

Your Qualifications

• Research-based master’s degree or equivalent (e.g. diploma) passed with an above-average grade in molecular life science, infection biology, neuroscience, biology, biomedicine, pharmacology or a related subject (if you are working on the master thesis and expect to graduate early in 2023, you can still apply)
• Excellent English language skills in speaking and writing
• Pro-active attitude, good communication skills and ability to work independently in an interdisciplinary team

How to Apply
Applications will be accepted till the position is filled. 

Please send the required documents (English or German) in one PDF to  Prof. Dr. Schwaninger:

• A detailed CV
• A letter of motivation
• Two letters of recommendation
• Degree certificates and grade transcripts (Master’s and Bachelor’s Degrees)
• An abstract of master thesis

Tentative start: earliest March 2023.

Contact
Prof. Dr. Markus Schwaninger, markus.schwaninger@uni-luebeck.de, Phone: +49 451 3101 7200

For further information see  Bridging Brain Barriers: Pharmakologie und Toxikologie (uni-luebeck.de)