CNS Regeneration

Research Interests

Cerebrovascular diseases, such as stroke, brain hemorrhage, and dementia, are the leading causes of death and disability and present an enormous socioeconomic burden worldwide. Current estimates predict that their prevalence will further increase as 25% of the population will be over 65 years of age by 2030.

Current explicative models of these diseases account for signs and symptoms that are already present in affected patients. However, we now know that these diseases are life-spanning processes that start silently at least 20 to 30 years before symptoms are perceived. It is therefore difficult to identify real cause from mere consequences.

Our research group aims to identify the underlying etiology of cerebrovascular disease in addition to studying its pathophysiology in order to develop novel therapeutic options.

Our current projects are:

1. Unraveling the mechanisms of axonal degeneration after brain hemorrhage

2. Investigating the role of brain endothelial cell death in hemorrhagic and ischemic brain injury

3. Studying hypertension as a model to understand the lifespan vascular changes leading to cerebrovascular diseases

Funding

2018-2020: Fraunhofer Society MEF EnTireAxon

2018-2019: BMBF MERCEDES

2018-2019: BMBF NEPTUN

Selected Publications

Castillo X, Castro Obregón S, Gutiérrez Becker B, Gutiérrez-Ospina G, Karalis N, Khalil A, Lopez-Noguerola JS, Lozano Rodríguez L, Martínez-Martínez E, Perez-Cruz C, Pérez Velázquez J, Pina AL, Rubio K, Salazar Garcia HP, Syeda T, Vanoye Carlo A, Villringer A, Winek K, Zille M. Re-thinking the etiological framework of neurodegeneration. Front Neurosci. 2019 Jul 24;13:728. doi:10.3389/fnins.2019.00728. eCollection 2019.

Ikhsan M, Palumbo A, Rose D, Zille M, Boltze J. Stem cell-drug interactions: An important, but neglected aspect of future neuronal stem cell therapy. A systematic review and meta-analysis. Stem Cells Transl Med. 2019 Jul 16. doi: 10.1002/sctm.19-0020. [Epub ahead of print].

Zille M, Karuppagounder SS, Ratan RR. Ferroptosis in Neurons and Cancer Cells is Similar but Differentially Regulated by HDAC Inhibitors. eNeuro. 2019 Feb 15;6(1). pii: ENEURO.0263-18.2019. doi: 10.1523/ENEURO.0263-18.2019. eCollection 2019 Jan-Feb. PMID: 30783618.

Hemorrhagic Stroke Academia Industry (HEADS) Roundtable Participants. Selim M, Hanley D, Broderick J, Keep R, Shoamanesh A, Ziai W, Singh V, Sheth K, Rosenblum M, Palesch Y, Muehlschlegel S, Kersten J, Mendelow DA, Gurol E, Gonzales N, Falcone G, Gregson B, Goldstein J, Zille M, Xi G, Ratan RR, James M, Sansing L, Aronowski J, Genstler C. Unmet Needs and Challenges in Clinical Research of Intracerebral Hemorrhage. Stroke. 2018 May;49(5):1299-1307. doi: 10.1161/STROKEAHA.117.019541. Epub 2018 Apr 4. Review. PMID: 29618558.

Hemorrhagic Stroke Academia Industry (HEADS) Roundtable Participants. Selim M, Hanley D, Keep R, Aronowski J, Genstler C, James M, Ratan RR, Sansing L, Youd A, Xi G, Zille M, Broderick J, Goldstein J, Gregson B, Falcone G, Gonzales N, Gurol E, Kersten J, Lewkowicz H, Mendelow DA, Muehlschlegel S, Neuman R, Palesch Y, Rosenblum M, Sheth K, Singh V, Ziai W, Anderson C, Awad I, Bastings E, Bednar M, Coon A, Gottesman R, Katz B, Khan S, Koroshetz W, Moy C, Koenig J, Torbey M, Vespa P, Steiner T, Zucarrello M, Wakhloo A, Tymianski M, Shoamanesh A, Pollack C, Marler J, Ling S, Loftus C, Louis T, Pena C, Omert L, Singer M, Zheng X, Keita M, Braun B, and Norton C. Basic and Translational Research in Intracerebral Hemorrhage: Limitations, Priorities, and Recommendations. Stroke. 2018 May;49(5):1308-1314. doi: 10.1161/STROKEAHA.117.019539. Epub 2018 Apr 4. Review. PMID: 29618555.

Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR. Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis. Stroke. 2017 Apr;48(4):1033-1043. doi: 10.1161/STROKEAHA.116.015609. Epub 2017 Mar 1. PMID: 28250197.